Macrophages in immunoregulation and therapeutics

S Chen, AFUH Saeed, Q Liu, Q Jiang, H Xu… - … and Targeted Therapy, 2023 - nature.com
Macrophages exist in various tissues, several body cavities, and around mucosal surfaces
and are a vital part of the innate immune system for host defense against many pathogens …

Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials

Y Shi, H Zhang, S Huang, L Yin, F Wang… - … and Targeted Therapy, 2022 - nature.com
Epigenetics is closely related to cardiovascular diseases. Genome-wide linkage and
association analyses and candidate gene approaches illustrate the multigenic complexity of …

Epigenetics in health and disease

L Zhang, Q Lu, C Chang - Epigenetics in allergy and autoimmunity, 2020 - Springer
Epigenetic mechanisms, which include DNA methylation, histone modification, and
microRNA (miRNA), can produce heritable phenotypic changes without a change in DNA …

Targeting early atherosclerosis: a focus on oxidative stress and inflammation

P Marchio, S Guerra-Ojeda, JM Vila… - Oxidative medicine …, 2019 - Wiley Online Library
Atherosclerosis is a chronic vascular inflammatory disease associated to oxidative stress
and endothelial dysfunction. Oxidation of low‐density lipoprotein (LDL) cholesterol is one of …

Update on anti-inflammatory molecular mechanisms induced by oleic acid

C Santa-María, S López-Enríquez… - Nutrients, 2023 - mdpi.com
In 2010, the Mediterranean diet was recognized by UNESCO as an Intangible Cultural
Heritage of Humanity. Olive oil is the most characteristic food of this diet due to its high …

Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms

FM Davis, LC Tsoi, WJ Melvin, A DenDekker… - Journal of Experimental …, 2021 - rupress.org
Abdominal aortic aneurysms (AAAs) are a life-threatening disease for which there is a lack
of effective therapy preventing aortic rupture. During AAA formation, pathological vascular …

Epigenetic regulation of macrophage polarization in wound healing

C Chen, T Liu, Y Tang, G Luo, G Liang, W He - Burns & Trauma, 2023 - academic.oup.com
The immune microenvironment plays a critical role in regulating skin wound healing.
Macrophages, the main component of infiltrating inflammatory cells, play a pivotal role in …

Epigenetics of atherosclerosis: emerging mechanisms and methods

N Khyzha, A Alizada, MD Wilson, JE Fish - Trends in molecular medicine, 2017 - cell.com
Atherosclerosis is a vascular pathology characterized by inflammation and plaque build-up
within arterial vessel walls. Vessel occlusion, often occurring after plaque rupture, can result …

Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics

S Xu, D Kamato, PJ Little, S Nakagawa… - Pharmacology & …, 2019 - Elsevier
Atherosclerosis, the principal cause of cardiovascular death worldwide, is a pathological
disease characterized by fibro-proliferation, chronic inflammation, lipid accumulation, and …

[HTML][HTML] Therapeutic Potential of Natural Compounds Acting through Epigenetic Mechanisms in Cardiovascular Diseases: Current Findings and Future Directions

P Bontempo, L Capasso, L De Masi, A Nebbioso… - Nutrients, 2024 - mdpi.com
Cardiovascular diseases (CVDs) remain a leading global cause of morbidity and mortality.
These diseases have a multifaceted nature being influenced by a multitude of biochemical …