Tissue-resident immune cells span both myeloid and lymphoid cell lineages, have been
found in multiple human tissues, and play integral roles at all stages of the immune …

B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …

T lymphocytes migrate to barrier sites after exposure to pathogens, providing localized
immunity and long-term protection. Here, we obtained blood and tissues from human organ …

Infancy and childhood are critical life stages for generating immune memory to protect
against pathogens; however, the timing, location, and pathways for memory development in …

HIV persists in tissues during antiretroviral therapy (ART), but the relative contribution of
different anatomical compartments to the viral reservoir in humans remains unknown. We …

SARS-CoV-2 infection for most children results in mild or minimal symptoms, though in rare
cases severe disease can develop, including a multisystem inflammatory syndrome (MIS-C) …

The persistence of anti-viral immunity is essential for protection and exhibits profound
heterogeneity across individuals. Here, we elucidate the factors that shape maintenance …

Memory T cells are fundamental to maintain immune surveillance of the human body. During
the past decade, it has become apparent that non-recirculating resident memory T cells …

Abstract CD4+ and CD8+ T lymphocytes mediate most of the adaptive immune response
against tumors. Naïve T lymphocytes specific for tumor antigens are primed in lymph nodes …

CD8 T lymphocytes are classically viewed as cytotoxic T cells. Whether human CD8 T cells
can, in parallel, induce a tissue regeneration program is poorly understood. Here, antigen …