The pancreas is made from two distinct components: the exocrine pancreas, a reservoir of
digestive enzymes, and the endocrine islets, the source of the vital metabolic hormone …

Menin inhibitors are novel targeted agents currently in clinical development for the treatment
of genetically defined subsets of acute leukemia. Menin has a tumor suppressor function in …

The hypothalamic control of prolactin secretion is different from other anterior pituitary
hormones, in that it is predominantly inhibitory, by means of dopamine from the …

Replenishing insulin-producing pancreatic b cell mass will benefit both type I and type II
diabetics. In adults, pancreatic b cells are generated primarily by self-duplication. We report …

Diabetes is the result of having inadequate supply of functional insulin-producing β cells.
Two possible approaches for replenishing the β cells are:(1) replacement by transplanting …

During pregnancy, the energy requirements of the fetus impose changes in maternal
metabolism. Increasing insulin resistance in the mother maintains nutrient flow to the …

The embryonic stem (ES) cell transcriptional and chromatin-modifying networks are critical
for self-renewal maintenance. However, it remains unclear whether these networks …

Prolactin is a hormone that is mainly secreted by lactotroph cells of the anterior pituitary
gland, and is involved in many biological processes including lactation and reproduction …

Pregnancy in placental mammals places unique demands on the insulin‐producing β‐cells
in the pancreatic islets of Langerhans. The pancreas anticipates the increase in insulin …

Aims/hypothesis We sought to establish the extent and basis for adaptive changes in beta
cell numbers in human pregnancy. Methods Pancreas was obtained at autopsy from women …