Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis

RF Little, C Hertweck - Natural Product Reports, 2022 - pubs.rsc.org
Review covering up to mid-2021 The structure of polyketide and non-ribosomal peptide
natural products is strongly influenced by how they are released from their biosynthetic …

Curiouser and curiouser: progress in understanding the programming of iterative highly-reducing polyketide synthases

RJ Cox - Natural Product Reports, 2023 - pubs.rsc.org
Covering: 1996–2022 Investigations over the last 2 decades have begun to reveal how
fungal iterative highly-reducing polyketide synthases are programmed. Both in vitro and in …

Genome mining for unknown–unknown natural products

DA Yee, K Niwa, B Perlatti, M Chen, Y Li… - Nature chemical …, 2023 - nature.com
Genome mining of biosynthetic pathways with no identifiable core enzymes can lead to
discovery of the so-called unknown (biosynthetic route)–unknown (molecular structure) …

Structural enzymology of iterative type I polyketide synthases: various routes to catalytic programming

J Wang, Z Deng, J Liang, Z Wang - Natural Product Reports, 2023 - pubs.rsc.org
Time span of literature covered: up to mid-2023 Iterative type I polyketide synthases (iPKSs)
are outstanding natural chemists: megaenzymes that repeatedly utilize their catalytic …

Strobilurin biosynthesis in Basidiomycete fungi

R Nofiani, K de Mattos-Shipley, KE Lebe… - Nature …, 2018 - nature.com
Strobilurins from fungi are the inspiration for the creation of the β-methoxyacrylate class of
agricultural fungicides. However, molecular details of the biosynthesis of strobilurins have …

Biosynthesis of fungal polyketides by collaborating and trans-acting enzymes

E Skellam - Natural Product Reports, 2022 - pubs.rsc.org
Covering: 1999 up to 2021 Fungal polyketides encompass a range of structurally diverse
molecules with a wide variety of biological activities. The giant multifunctional enzymes that …

Assessing the Biosynthetic Inventory of the Biocontrol Fungus Trichoderma afroharzianum T22

W Han, Z Wu, Z Zhong, J Williams… - Journal of agricultural …, 2023 - ACS Publications
Natural products biosynthesized from biocontrol fungi in the rhizosphere can have both
beneficial and deleterious effects on plants. Herein, we performed a comprehensive …

Biosynthesis of Fusapyrone Depends on the H3K9 Methyltransferase, FmKmt1, in Fusarium mangiferae

AK Atanasoff-Kardjalieff, F Lünne, S Kalinina… - Frontiers in Fungal …, 2021 - frontiersin.org
The phytopathogenic fungus Fusarium mangiferae belongs to the Fusarium fujikuroi species
complex (FFSC). Members of this group cause a wide spectrum of devastating diseases on …

Biosynthesis of the Isocoumarin Derivatives Fusamarins is Mediated by the PKS8 Gene Cluster in Fusarium

AK Atanasoff‐Kardjalieff, B Seidl, K Steinert… - …, 2023 - Wiley Online Library
Fusarium mangiferae causes the mango malformation disease (MMD) on young mango
trees and seedlings resulting in economically significant crop losses. In addition, F …

Synthaser: a CD-Search enabled Python toolkit for analysing domain architecture of fungal secondary metabolite megasynth (et) ases

CLM Gilchrist, YH Chooi - Fungal Biology and Biotechnology, 2021 - Springer
Background Fungi are prolific producers of secondary metabolites (SMs), which are
bioactive small molecules with important applications in medicine, agriculture and other …