Regression of cardiac hypertrophy in health and disease: mechanisms and therapeutic potential

TG Martin, MA Juarros, LA Leinwand - Nature Reviews Cardiology, 2023 - nature.com
Left ventricular hypertrophy is a leading risk factor for cardiovascular morbidity and mortality.
Although reverse ventricular remodelling was long thought to be irreversible, evidence from …

Apoptosis regulation by the tyrosine-protein kinase CSK

A Fortner, A Chera, A Tanca, O Bucur - Frontiers in cell and …, 2022 - frontiersin.org
C-terminal Src kinase (CSK) is a cytosolic tyrosine-protein kinase with an important role in
regulating critical cellular decisions, such as cellular apoptosis, survival, proliferation …

Expression of soluble ST2 in patients with essential hypertension and its relationship with left ventricular hypertrophy

P Wei, L Liu, X Wang, B Zong, X Liu, M Zhang… - ESC Heart …, 2023 - Wiley Online Library
Aims Identification and intervention of left ventricular hypertrophy (LVH) in essential
hypertension (EH) are important for the prevention of adverse cardiovascular events …

Promising therapies for atrial fibrillation and ventricular tachycardia

AA Mircea, M Rusu, EA Liehn, O Bucur - International Journal of …, 2022 - mdpi.com
Sudden cardiac death due to arrhythmias, such as atrial fibrillation or ventricular
tachycardia, account for 15–20% of all deaths. Myocardial infarction increases the burden of …

[HTML][HTML] Heart function assessment during aging in apolipoprotein E knock-out mice

EA Liehn, AM Lupan, R Diaconu, M Ioana, I Streata… - Discoveries, 2021 - ncbi.nlm.nih.gov
BACKGROUND: Apolipoprotein (apo) E isoforms have strong correlations with metabolic
and cardiovascular diseases. However, it is not clear if apoE has a role in development of …

[HTML][HTML] Fenofibrate reduces cardiac remodeling by mitochondrial dynamics preservation in a renovascular model of cardiac hypertrophy

L Castiglioni, P Gelosa, M Muluhie, B Mercuriali… - European Journal of …, 2024 - Elsevier
Fenofibrate, a PPAR-α agonist clinically used to lower serum lipid levels, reduces cardiac
remodeling and improves cardiac function. However, its mechanism of action is not …

Cost Effectiveness of the First‐in‐Class ARNI (Sacubitril/Valsartan) for the Treatment of Essential Hypertension in a Chinese Setting

X Dong, X He, J Wu - Pharmacoeconomics, 2022 - Springer
Objective The aim of this study was to model the potential long-term disease progression
and pharmacoeconomic value of sacubitril/valsartan for the treatment of essential …

[HTML][HTML] Reversal of hypertensive heart disease: a multiple linear regression model

SN Ahmed, R Jhaj, B Sadasivam, R Joshi - Discoveries, 2021 - ncbi.nlm.nih.gov
Background: The development of left ventricular hypertrophy in primary hypertension
increases cardiovascular mortality and morbidity. Reversal of left ventricular hypertrophy …

[HTML][HTML] The correlation between serum fibroblast growth factor-23 levels and left ventricular hypertrophy in chronic kidney disease patients

AMAA Karim, H Kasim, A Albaar… - Journal of Renal Injury …, 2023 - journalrip.com
Introduction: Hyperphosphatemia in chronic kidney disease (CKD) patients can stimulate the
production of the fibroblast growth factor-23 (FGF-23) phosphatonin hormone, which is …

Sex-based differences in left ventricular mass reduction across angiotensin II receptor blockers in patients with heart failure with preserved or mildly reduced ejection …

M Amano, C Izumi, S Ito, M Kitakaze - Heart and Vessels, 2024 - Springer
Although angiotensin II receptor blockers (ARBs) are more effective in women for either
reduction of blood pressure or heart failure (HF), the gender disparities and the impact of …