Parkinson's disease (PD) is a neurodegenerative disorder due to dopamine deficit in
substatia nigra. PD is mainly a sporadic disease with unestablished etiology. However …

Neurodegenerative and neuropsychiatric diseases are increasingly affecting individuals'
quality of life, thus increasing their cost to social and health systems. These diseases have …

The two major neurodegenerative diseases Alzheimer's disease (AD) and Parkinson's
disease (PD) are characterised by low levels in the brain of the neurotransmitters …

Mucuna pruriens possesses significantly higher antiparkinson activity compared with
levodopa in the 6-hydroxydopamine (6-OHDA) lesioned rat model of Parkinson's disease …

In mammals, sexual hormones such as estrogens play an essential role in maintaining brain
homeostasis and function. Estrogen deficit in the brain induces many undesirable symptoms …

Small-molecule natural products (NPs) have a long and successful track record of providing
first-in-class drugs and pharmacophore (scaffolds) in all therapeutic areas, serving as a …

Parkinson disease (PD) is a multifactorial disease, where a genetic predisposition combines
with putative environmental risk factors. Mounting evidence suggests that the initial PD …

Dopaminergic anti-parkinsonian medications, such as levodopa (LD) cause drug-induced
dyskinesias (DID) in majority of patients with Parkinson's disease (PD). Mucuna pruriens, a …

The medicinal plant Mucuna pruriens (Fabaceae) is widely known for its anti-oxidative and
anti-inflammatory properties. It is a well-established drug in Ayurveda and has been widely …

Parkinson's disease (PD) is a neurodegenerative disorder which is characterized by typical
symptoms including gradual progressive muscle rigidity, tremor and loss of motor skills …