Electroencephalographic (EEG) biomarkers in genetic neurodevelopmental disorders

K Goodspeed, D Armstrong, A Dolce… - Journal of child …, 2023 - journals.sagepub.com
Collectively, neurodevelopmental disorders are highly prevalent, but more than a third of
neurodevelopmental disorders have an identifiable genetic etiology, each of which is …

Sex-Related Changes in the Clinical, Genetic, Electrophysiological, Connectivity, and Molecular Presentations of ASD: A Comparison between Human and Animal …

A Ornoy, D Gorobets, L Weinstein-Fudim… - International Journal of …, 2023 - mdpi.com
The etiology of autism spectrum disorder (ASD) is genetic, environmental, and epigenetic. In
addition to sex differences in the prevalence of ASD, which is 3–4 times more common in …

[HTML][HTML] Phenotypic analysis of multielectrode array EEG biomarkers in developing and adult male Fmr1 KO mice

CR Jonak, SA Assad, TA Garcia, MS Sandhu… - Neurobiology of …, 2024 - Elsevier
Abstract Fragile X Syndrome (FXS) is a leading known genetic cause of intellectual disability
with symptoms that include increased anxiety and social and sensory processing deficits …

Rescue of sharp wave-ripples and prevention of network hyperexcitability in the ventral but not the dorsal hippocampus of a rat model of fragile X syndrome

LJ Leontiadis, G Trompoukis, G Tsotsokou… - Frontiers in cellular …, 2023 - frontiersin.org
Fragile X syndrome (FXS) is a genetic neurodevelopmental disorder characterized by
intellectual disability and is related to autism. FXS is caused by mutations of the fragile X …

Ketogenic diet affects sleep architecture in C57BL/6J wild type and fragile X mice

PR Westmark, AK Gholston, TJ Swietlik… - International Journal of …, 2023 - mdpi.com
Nearly half of children with fragile X syndrome experience sleep problems including trouble
falling asleep and frequent nighttime awakenings. The goals here were to assess sleep …

Combined extended reality and reinforcement learning to promote healthcare and reduce social anxiety in fragile X syndrome: a new assessment tool and a …

F Stasolla, A Passaro, M Di Gioia, E Curcio… - Frontiers in …, 2023 - frontiersin.org
Fragile X syndrome (FXS) is a rare genetic disease caused by mutations in the fifth
untranslated region of the FMRI gene situated on the Xq27. 3 site, resulting in an expansion …

[HTML][HTML] Clinically-probed mechanisms of action in Fragile-X syndrome fail to normalize translational EEG phenotypes in Fmr1 knockout mice

P Janz, M Bainier, S Marashli, S Gross, RL Redondo - Neuropharmacology, 2025 - Elsevier
Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by Fragile X
Messenger Ribonucleoprotein (FMRP) deficiency. Electroencephalogram (EEG) changes in …

Association of Intrinsic Functional Brain Network and Longitudinal Development of Cognitive Behavioral Symptoms in Young Girls With Fragile X Syndrome

R Li, AA Lightbody, CH Lee, KL Bartholomay… - Biological …, 2023 - Elsevier
Abstract Background Fragile X syndrome (FXS) is an X chromosome–linked genetic
disorder characterized by increased risk for behavioral, social, and neurocognitive deficits …

Adult Inception of Ketogenic Diet Therapy Increases Sleep during the Dark Cycle in C57BL/6J Wild Type and Fragile X Mice

PR Westmark, TJ Swietlik, E Runde, B Corsiga… - International Journal of …, 2024 - mdpi.com
Sleep problems are a significant phenotype in children with fragile X syndrome. Our prior
work assessed sleep–wake cycles in Fmr1KO male mice and wild type (WT) littermate …

Results from a Double-Blind, Randomized, Placebo-Controlled, Single-Dose, Crossover Trial of Lovastatin or Minocycline in Fragile X Syndrome

WS McKinney, LM Schmitt, LA De Stefano… - Journal of Child and …, 2024 - liebertpub.com
Introduction: Treatment studies in FMR1 knockout rodent models have found that
minocycline and lovastatin each improve synaptic, neurological, and behavioral functioning …