Homologous recombination (HR) is a major pathway for the repair of DNA double-strand
breaks in mammalian cells, the defining step of which is homologous strand exchange …

Recombinational DNA repair is a universal aspect of DNA metabolism and is essential for
genomic integrity. It is a template-directed process that uses a second chromosomal copy …

Bloom's syndrome (BS) is an autosomal recessive disorder characterized by a strong cancer
predisposition. The defining feature of BS is extreme genome instability. The gene mutated …

Homologous recombination (HR) is a primary DNA double-strand breaks (DSBs) repair
mechanism. The recombinases Rad51 and Dmc1 are highly conserved in the RecA family; …

The complete and faithful duplication of the genome is an essential prerequisite for
proliferating cells to maintain genome integrity. This objective is greatly challenged by DNA …

Recombinase proteins assembled into helical filaments on DNA are believed to be the
catalytic core of homologous recombination. The assembly, disassembly and dynamic …

The repair of DNA by homologous recombination is an essential, efficient, and high-fidelity
process that mends DNA lesions formed during cellular metabolism; these lesions include …

O6-methylguanine (O6MeG) is a highly critical DNA adduct induced by methylating
carcinogens and anticancer drugs such as temozolomide, streptozotocine, procarbazine …

The year 2004 represents a milestone for the biosensor research community: in this year,
over 1000 articles were published describing experiments performed using commercially …

The RAD51 recombinase forms nucleoprotein filaments to promote double-strand break
repair, replication fork reversal, and fork stabilization. The stability of these filaments is highly …