Progress and renewal in gustation: new insights into taste bud development

LA Barlow - Development, 2015 - journals.biologists.com
The sense of taste, or gustation, is mediated by taste buds, which are housed in specialized
taste papillae found in a stereotyped pattern on the surface of the tongue. Each bud …

Biological effects of space radiation and development of effective countermeasures

AR Kennedy - Life sciences in space research, 2014 - Elsevier
As part of a program to assess the adverse biological effects expected from astronauts'
exposure to space radiation, numerous different biological effects relating to astronauts' …

Taste bud homeostasis in health, disease, and aging

P Feng, L Huang, H Wang - Chemical senses, 2014 - academic.oup.com
The mammalian taste bud is an onion-shaped epithelial structure with 50–100 tightly packed
cells, including taste receptor cells, supporting cells, and basal cells. Taste receptor cells …

Potential Protective Effects of Antioxidants against Cyclophosphamide‐Induced Nephrotoxicity

MA Ayza, KA Zewdie, EF Yigzaw… - International Journal …, 2022 - Wiley Online Library
Cyclophosphamide is an alkylating antineoplastic agent, and it is one of the most successful
drugs with wide arrays of clinical activity. It has been in use for several types of cancer …

Characteristics of taste alterations in people receiving taxane-based chemotherapy and their association with appetite, weight, and quality of life

M Kaizu, H Komatsu, H Yamauchi, T Yamauchi… - Supportive Care in …, 2021 - Springer
Purpose There is limited evidence on the effect of chemotherapy-associated taste alteration.
This study aimed to evaluate taste alteration characteristics in patients receiving taxane …

Factors contributing to the duration of chemotherapy-induced severe oral mucositis in oncopediatric patients

LCL Damascena, NNN De Lucena, ILA Ribeiro… - International Journal of …, 2018 - mdpi.com
This study analyzes the factors contributing to the duration of severe oral mucositis in
oncopediatric patients. A longitudinal study was conducted in the pediatric department of a …

Cellular mechanisms of cyclophosphamide-induced taste loss in mice

N Mukherjee, S Pal Choudhuri, RJ Delay, ER Delay - PloS one, 2017 - journals.plos.org
Many commonly prescribed chemotherapy drugs such as cyclophosphamide (CYP) have
adverse side effects including disruptions in taste which can result in loss of appetite …

SOD2 Mediates Amifostine‐Induced Protection against Glutamate in PC12 Cells

J Jia, L Zhang, X Shi, M Wu, X Zhou… - … medicine and cellular …, 2016 - Wiley Online Library
Background. Cytoprotectant amifostine attenuates radiation‐induced oxidative injury by
increasing intracellular manganese superoxide dismutase (SOD2) in peripheral tissue …

Cyclophosphamide and the taste system: Effects of dose fractionation and amifostine on taste cell renewal

ER Delay, SH Socia, JL Girardin, BC Jewkes, JH King… - PLoS …, 2019 - journals.plos.org
Chemotherapy often causes side effects that include disturbances in taste functions.
Cyclophosphamide (CYP) is a chemotherapy drug that, after a single dose, elevates murine …

The mystery of “metal mouth” in chemotherapy

AJM Reith, C Spence - Chemical senses, 2020 - academic.oup.com
Of all the oral sensations that are experienced,“metallic” is one that is rarely reported in
healthy participants. So why, then, do chemotherapy patients so frequently report that …