From influenza to COVID-19: Lipid nanoparticle mRNA vaccines at the frontiers of infectious diseases

EH Pilkington, EJA Suys, NL Trevaskis, AK Wheatley… - Acta biomaterialia, 2021 - Elsevier
Vaccination represents the best line of defense against infectious diseases and is crucial in
curtailing pandemic spread of emerging pathogens to which a population has limited …

Aceclofenac and methotrexate combination therapy could influence Th1/Th17 axis to modulate rheumatoid-arthritis-induced inflammation

S Negi, N Tandel, P Sharma, R Kumar, RK Tyagi - Drug Discovery Today, 2023 - Elsevier
Rheumatoid arthritis (RA) is an inflammatory, autoimmune and connective-tissue
arthropathy. The methotrexate (MTX) and aceclofenac (ACL) combination drug regimen is …

Nanostructured lipid carrier–mediated transdermal delivery of aceclofenac hydrogel present an effective therapeutic approach for inflammatory diseases

NK Garg, N Tandel, SK Bhadada… - Frontiers in …, 2021 - frontiersin.org
Aceclofenac (ACE), a cyclooxygenase-2 inhibitor, is the derivative of the diclofenac group
that has been in use for the symptomatic treatment of systemic inflammatory autoimmune …

Novel pharmaceutical strategies for enhancing skin penetration of biomacromolecules

L Zhang, Z Dong, W Liu, X Wu, H He, Y Lu, W Wu, J Qi - Pharmaceuticals, 2022 - mdpi.com
Skin delivery of biomacromolecules holds great advantages in the systemic and local
treatment of multiple diseases. However, the densely packed stratum corneum and the tight …

Mannose-modified erythrocyte membrane-encapsulated chitovanic nanoparticles as a DNA vaccine carrier against reticuloendothelial tissue hyperplasia virus

Y Feng, F Tang, S Li, D Wu, Q Liu, H Li… - Frontiers in …, 2023 - frontiersin.org
Introduction The erythrocyte membranes used in nanovaccines include high membrane
stability, long circulation life, adaptability and extremely good bio compatibility …

Nanocarrier-based approaches for the efficient delivery of anti-tubercular drugs and vaccines for management of tuberculosis

A Rajput, S Mandlik, V Pokharkar - Frontiers in Pharmacology, 2021 - frontiersin.org
Drug-resistant species of tuberculosis (TB), which spread faster than traditiona TB, is a
severely infectious disease. The conventional drug therapy used in the management of …

[HTML][HTML] Nanotechnology platforms for antigen and immunostimulant delivery in vaccine formulations

PG Marquez, FJ Wolman, RJ Glisoni - Nano Trends, 2024 - Elsevier
Vaccines represent a cornerstone in global health history, marking one of the most
significant scientific achievements. Initially consisting of live or attenuated microorganisms …

Pseudovirus Nanoparticles Displaying Plasmodium Circumsporozoite Proteins Elicited High Titers of Sporozoite-Binding Antibody

M Xia, P Huang, F Vago, W Jiang, M Tan - Vaccines, 2023 - mdpi.com
Background: malaria caused by Plasmodium parasites remains a public health threat. The
circumsporozoite proteins (CSPs) of Plasmodium sporozoite play a key role in Plasmodium …

Adjuvants in cutaneous vaccination: A comprehensive analysis

M Oladejo, AO Tijani, A Puri, L Chablani - Journal of Controlled Release, 2024 - Elsevier
Skin is the body's largest organ and serves as a protective barrier from physical, thermal,
and mechanical environmental challenges. Alongside, the skin hosts key immune system …

Biogenically synthesized green silver nanoparticles exhibit antimalarial activity

S Tiwari, R Kumar, S Devi, P Sharma, NR Chaudhary… - Discover nano, 2024 - Springer
The suboptimal efficacies of existing anti-malarial drugs attributed to the emergence of drug
resistance dampen the clinical outcomes. Hence, there is a need for developing novel drug …