Abstract Interleukin (IL)-10 is an essential anti-inflammatory cytokine and functions as a
negative regulator of immune responses to microbial antigens. IL-10 is particularly important …

The microbiota is an important factor in the development of the immune response. The
interaction between the gastrointestinal tract and resident microbiota is well balanced in …

We performed a genome-wide association study (GWAS) of IgA nephropathy (IgAN), the
most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals …

Fecal IgA production depends on colonization by a gut microbiota. However, the bacterial
strains that drive gut IgA production remain largely unknown. Here, we assessed the IgA …

Throughout a 24-h period, the small intestine (SI) is exposed to diurnally varying food-and
microbiome-derived antigenic burdens but maintains a strict immune homeostasis, which …

Black men die more often of prostate cancer yet, interestingly, may derive greater survival
benefits from immune-based treatment with sipuleucel-T. Since no signatures of immune …

Throughout the last years, gut-resident Foxp3+ regulatory T (Treg) cells have been
associated with a growing number of tissue-specific functions in the intestine, comprising …

The immune system has developed strategies to maintain a homeostatic relationship with
the resident microbiota. IgA is central in holding this relationship, as the most dominant …

Plasma cells (PCs) represent the terminal differentiation step of mature B lymphocytes.
These cells are most recognizable for their extended lifespan as well as their ability to …

The evolutionary strategy of transferring maternal antibodies via milk profoundly impacts the
survival, lifelong health, and wellbeing of all neonates, including a pronounced impact on …