Molecular mechanisms of transgenerational epigenetic inheritance

MH Fitz-James, G Cavalli - Nature Reviews Genetics, 2022 - nature.com
Increasing evidence indicates that non-DNA sequence-based epigenetic information can be
inherited across several generations in organisms ranging from yeast to plants to humans …

Epigenetic inheritance of polycystic ovary syndrome—challenges and opportunities for treatment

E Stener-Victorin, Q Deng - Nature Reviews Endocrinology, 2021 - nature.com
Polycystic ovary syndrome (PCOS) is the main cause of female infertility worldwide and is
associated with a substantially increased lifetime risk of comorbidities, including type 2 …

Dissecting early life stress-induced adolescent depression through epigenomic approach

S Ochi, Y Dwivedi - Molecular psychiatry, 2023 - nature.com
Early life stress (ELS), such as abuse and neglect during childhood, can lead to psychiatric
disorders in later life. Previous studies have suggested that ELS can cause profound …

[图书][B] RNA, the epicenter of genetic information

J Mattick, P Amaral - 2023 - library.oapen.org
The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Connecting the dots: linking Caenorhabditis elegans small RNA pathways and germ granules

AE Sundby, RI Molnar, JM Claycomb - Trends in Cell Biology, 2021 - cell.com
Germ granules are non-membrane bound, phase-separated organelles, composed of RNAs
and proteins. Germ granules are present only within the germ cells of animals, including …

The evolutionary significance of RNAi in the fungal kingdom

C Lax, G Tahiri, JA Patiño-Medina… - International Journal of …, 2020 - mdpi.com
RNA interference (RNAi) was discovered at the end of last millennium, changing the way
scientists understood regulation of gene expression. Within the following two decades, a …

Plant responses to biotic stress: Old memories matter

A Bhar, A Chakraborty, A Roy - Plants, 2021 - mdpi.com
Plants are fascinating organisms present in most ecosystems and a model system for
studying different facets of ecological interactions on Earth. In the environment, plants …

An essential role for the piRNA pathway in regulating the ribosomal RNA pool in C. elegans

L Wahba, L Hansen, AZ Fire - Developmental cell, 2021 - cell.com
Piwi-interacting RNAs (piRNAs) are RNA effectors with key roles in maintaining genome
integrity and promoting fertility in metazoans. In Caenorhabditis elegans loss of piRNAs …

Transgenerational plasticity in the context of predator-prey interactions

J Tariel, S Plénet, É Luquet - Frontiers in Ecology and Evolution, 2020 - frontiersin.org
Almost all animal species are engaged in predator-prey interactions. These interactions,
variable in time and space, favor the emergence and evolution of phenotypic plasticity …

A Kuhnian revolution in molecular biology: Most genes in complex organisms express regulatory RNAs

JS Mattick - Bioessays, 2023 - Wiley Online Library
Thomas Kuhn described the progress of science as comprising occasional paradigm shifts
separated by interludes of 'normal science'. The paradigm that has held sway since the …