Cancer immunotherapies have made much headway during the past decades. Techniques
including the immune checkpoint inhibition (ICI) and adoptive cell therapy (ACT) have …

In the spectrum of colorectal tumors, microsatellite-stable (MSS) tumors with DNA
polymerase ε (POLE) mutations exhibit a hypermutated profile, holding the potential to …

Objective: Studies have demonstrated an association between somatic POLE exonuclease
domain mutations (EDMs) and the prognosis of colorectal cancer (CRC). However, the …

BAP1-inactivated melanocytic tumor (BIMT) is a group of melanocytic neoplasms with
epithelioid cell morphology molecularly characterized by the loss of function of BAP1, a …

Background Sarcomatoid carcinoma (SC) of the head and neck (HN) is a rare disease that
has both sarcomatoid and cancerous components. The genetic background and …

摘要阐述了DNA 聚合酶ɛ (polymerase epsilon, POLE) 和DNA 聚合酶delta 1 (polymerase
delta 1, POLD1) 基因编码的亚基参与DNA 复制和校对, 总结了POLE/POLD1 …

Colon cancer (CC) is one of the most frequent cancers worldwide being responsible for over
500 thousand deaths in 2022. Its financial and human burden is expected to increase in the …

BACKGROUND Colorectal liver metastases (CLM) occur in 15%-30% of patients with
colorectal cancer (CRC). Advancements in next generation sequencing (NGS) can provide …

Somatic and germline molecular analysis and morphological aspects of unusual variants of
malignant melanomas and uncommon melanocytic neoplasms Abstract Background: The …

Background: The histopathological diagnosis of melanocytic tumors represented one of the
greatest challenges of pathology. In the last years, the concept of melanoma as a single …