The division of the cellular space into nucleoplasm and cytoplasm promotes quality control
mechanisms that prevent misprocessed mRNAs and junk RNAs from gaining access to the …

RNA stability and quality control are integral parts of gene expression regulation. A key
factor shaping eukaryotic transcriptomes, mainly via 3′–5′ exoribonucleolytic trimming or …

Most mammalian genes have multiple polyA sites, representing a substantial source of
transcript diversity regulated by the cleavage and polyadenylation (CPA) machinery. To …

Termination of RNA polymerase II (RNAPII) transcription in metazoans relies largely on the
cleavage and polyadenylation (CPA) and integrator (INT) complexes originally found to act …

The RNA-binding ARS2 protein is centrally involved in both early RNA polymerase II
(RNAPII) transcription termination and transcript decay. Despite its essential nature, the …

The best-studied mechanism of eukaryotic RNA polymerase II (RNAPII) transcriptional
termination involves polyadenylation site-directed cleavage of the nascent RNA. The RNAPII …

RNA surveillance pathways detect and degrade defective transcripts to ensure RNA fidelity.
We found that disrupted nuclear RNA surveillance is oncogenic. Cyclin-dependent kinase …

Telomeric repeat-containing RNA (TERRA) is a long non-coding RNA transcribed from
telomeres that plays key roles in telomere maintenance. A fraction of TERRA is …

RNA quality control relies on co-factors and adaptors to identify and prepare substrates for
degradation by ribonucleases such as the 3′ to 5′ ribonucleolytic RNA exosome. Here …

Dyskeratosis congenita (DC) is a rare inherited bone marrow failure syndrome, caused by
genetic mutations that principally affect telomere biology. Approximately 35% of cases …