The current state of traumatic brain injury biomarker measurement methods

AD Krausz, FK Korley, MA Burns - Biosensors, 2021 - mdpi.com
Traumatic brain injury (TBI) is associated with high rates of morbidity and mortality partially
due to the limited tools available for diagnosis and classification. Measuring panels of …

Peripheral blood and salivary biomarkers of blood–brain barrier permeability and neuronal damage: clinical and applied concepts

D Janigro, DM Bailey, S Lehmann, J Badaut… - Frontiers in …, 2021 - frontiersin.org
Within the neurovascular unit (NVU), the blood–brain barrier (BBB) operates as a key
cerebrovascular interface, dynamically insulating the brain parenchyma from peripheral …

From biomechanics to pathology: predicting axonal injury from patterns of strain after traumatic brain injury

CK Donat, M Yanez Lopez, M Sastre, N Baxan… - Brain, 2021 - academic.oup.com
The relationship between biomechanical forces and neuropathology is key to understanding
traumatic brain injury. White matter tracts are damaged by high shear forces during impact …

Temporal Profiles of P-Tau, T-Tau, and P-Tau: Tau Ratios in Cerebrospinal Fluid and Blood from Moderate-Severe Traumatic Brain Injury Patients and Relationship to …

R Rubenstein, L McQuillan, KKW Wang… - Journal of …, 2024 - liebertpub.com
Traumatic brain injury (TBI) can initiate progressive injury responses, which are linked to
increased risk of neurodegenerative diseases known as “tauopathies.” Increased post-TBI …

Developing methods to detect and diagnose chronic traumatic encephalopathy during life: rationale, design, and methodology for the DIAGNOSE CTE Research …

ML Alosco, ML Mariani, CH Adler, LJ Balcer… - Alzheimer's research & …, 2021 - Springer
Background Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that
has been neuropathologically diagnosed in brain donors exposed to repetitive head …

Associations of longitudinal plasma p-tau181 and NfL with tau-PET, Aβ-PET and cognition

BS Rauchmann, T Schneider-Axmann… - Journal of Neurology …, 2021 - jnnp.bmj.com
Objective To explore if changes over time of plasma phosphorylated tau (p-tau) 181 and
neurofilament light chain (NfL) predict future tau and amyloid β (Aβ) PET load and cognitive …

Ketogenic diet as a potential treatment for traumatic brain injury in mice

M Har-Even, V Rubovitch, WA Ratliff… - Scientific reports, 2021 - nature.com
Traumatic brain injury (TBI) is a brain dysfunction without present treatment. Previous
studies have shown that animals fed ketogenic diet (KD) perform better in learning tasks …

Advances in Molecular Psychiatry – March 2023: mitochondrial function, stress, neuroinflammation – bipolar disorder, psychosis, and Alzheimer's disease

J Licinio, ML Wong - Molecular Psychiatry, 2023 - nature.com
In this issue of Molecular Psychiatry, we have multiple articles that present exciting
advances. Mitochondrial dysfunction is a topic that we are highlighting, and it is addressed …

Identifying degenerative effects of repetitive head trauma with neuroimaging: a clinically-oriented review

BM Asken, GD Rabinovici - Acta neuropathologica communications, 2021 - Springer
Abstract Background and Scope of Review Varying severities and frequencies of head
trauma may result in dynamic acute and chronic pathophysiologic responses in the brain …

Neurofilament light chain in patients with a concussion or head impacts: a systematic review and meta-analysis

E Karantali, D Kazis, J McKenna… - European journal of …, 2022 - Springer
Purpose Traumatic brain injury is one of the leading causes of disability worldwide. Mild
traumatic brain injury (TBI) is the most common and benign form of TBI, usually referred to by …