Developmental biology relies heavily on microscopy to image the finely controlled cell
behaviors that drive embryonic development. Most embryos are large enough that a field of …

Abstract Endocrine Disrupting Chemicals (EDCs) are molecules able to interfere with the
vertebrate hormonal system in different ways, a major one being the modification of the …

Ascidians (marine invertebrates: urochordates) are thought to be the closest sister groups of
vertebrates. They are particularly attractive models because of their non-duplicated genome …

In many animal embryos, germ-cell formation depends on maternal factors located in the
germ plasm. To ensure the development of germ cells, germline progenitors must be …

Mitotic spindle orientation with respect to cortical polarity cues generates molecularly distinct
daughter cells during asymmetric cell division (ACD). However, during ACD it remains …

The endocrine disruptor Bisphenol A (BPA), a widely employed molecule in plastics, has
been shown to affect several biological processes in vertebrates, mostly via binding to …

The spindle assembly checkpoint (SAC) is a surveillance system that preserves genome
integrity by delaying anaphase onset until all chromosomes are correctly attached to spindle …

Localization of maternal molecules in eggs and embryos and cytoplasmic movements to
relocalize them are fundamental for the orderly cellular and genetic processes during early …

A fundamental challenge in developmental biology is to understand how forces produced by
individual cells are patterned in space and time and then integrated to produce stereotyped …

The localization of mRNAs in developing animal cells is essential for establishing cellular
polarity and setting up the body plan for subsequent development. Cellular and molecular …