Huntington's disease is a progressive, fatal, neurodegenerative disorder caused by an
expanded CAG repeat in the huntingtin gene, which encodes an abnormally long …

Misfolding, aggregation, and aberrant accumulation of proteins are central components in
the progression of neurodegenerative disease. Cellular molecular chaperone systems …

Proteostasis is maintained by multiple cellular pathways, including protein synthesis, quality
control, and degradation. An imbalance of neuronal proteostasis, associated with protein …

Emerging evidence indicates that heat shock proteins (HSPs) are critical regulators in
normal neural physiological function as well as in cell stress responses. The functions of …

Huntington's disease (HD) is a devastating autosomal dominant neurodegenerative disease
caused by a CAG trinucleotide repeat expansion encoding an abnormally long …

Huntington's disease (HD) is an inherited progressive neurodegenerative disorder
associated with involuntary abnormal movements (chorea), cognitive deficits and psychiatric …

Expanded CAG repeats lead to debilitating neurodegenerative disorders characterized by
aggregation of proteins with expanded polyglutamine (polyQ) tracts. The mechanism of …

Histone deacetylase (HDAC) 4 is a transcriptional repressor that contains a glutamine-rich
domain. We hypothesised that it may be involved in the molecular pathogenesis of …

Small heat shock proteins are ubiquitously expressed chaperones, yet mutations in some of
them cause tissue-specific diseases. Here, we will discuss how small heat shock proteins …

T he stability of the proteome is crucial to the health of the cell, and contributes significantly
to the lifespan of the organism. Aging and many age-related diseases have in common the …