Mitochondrial quality control and disease: insights into ischemia-reperfusion injury

AR Anzell, R Maizy, K Przyklenk, TH Sanderson - Molecular neurobiology, 2018 - Springer
Mitochondria are key regulators of cell fate during disease. They control cell survival via the
production of ATP that fuels cellular processes and, conversely, cell death via the induction …

Fusion and fission: interlinked processes critical for mitochondrial health

DC Chan - Annual review of genetics, 2012 - annualreviews.org
Mitochondria are dynamic organelles that continually undergo fusion and fission. These
opposing processes work in concert to maintain the shape, size, and number of …

Human Fis1 regulates mitochondrial dynamics through inhibition of the fusion machinery

R Yu, SB Jin, U Lendahl, M Nistér, J Zhao - The EMBO journal, 2019 - embopress.org
Mitochondrial dynamics is important for life. At center stage for mitochondrial dynamics, the
balance between mitochondrial fission and fusion is a set of dynamin‐related GTP ases that …

Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission

OC Losón, Z Song, H Chen… - Molecular biology of the …, 2013 - Am Soc Cell Biol
Several mitochondrial outer membrane proteins—mitochondrial fission protein 1 (Fis1),
mitochondrial fission factor (Mff), mitochondrial dynamics proteins of 49 and 51 kDa (MiD49 …

AMPK/FIS1-mediated mitophagy is required for self-renewal of human AML stem cells

S Pei, M Minhajuddin, B Adane, N Khan, BM Stevens… - Cell stem cell, 2018 - cell.com
Leukemia stem cells (LSCs) are thought to drive the genesis of acute myeloid leukemia
(AML) as well as relapse following chemotherapy. Because of their unique biology …

FUNDC 1 regulates mitochondrial dynamics at the ER–mitochondrial contact site under hypoxic conditions

W Wu, C Lin, K Wu, L Jiang, X Wang, W Li… - The EMBO …, 2016 - embopress.org
In hypoxic cells, dysfunctional mitochondria are selectively removed by a specialized
autophagic process called mitophagy. The ER–mitochondrial contact site (MAM) is essential …

Binding of FUN14 domain containing 1 with inositol 1, 4, 5-trisphosphate receptor in mitochondria-associated endoplasmic reticulum membranes maintains …

S Wu, Q Lu, Q Wang, Y Ding, Z Ma, X Mao, K Huang… - Circulation, 2017 - Am Heart Assoc
Background: FUN14 domain containing 1 (FUNDC1) is a highly conserved outer
mitochondrial membrane protein. The aim of this study is to examine whether FUNDC1 …

[HTML][HTML] The endoplasmic reticulum–mitochondria connection: one touch, multiple functions

S Marchi, S Patergnani, P Pinton - Biochimica et Biophysica Acta (BBA) …, 2014 - Elsevier
The endoplasmic reticulum (ER) and mitochondria are tubular organelles with a
characteristic “network structure” that facilitates the formation of interorganellar connections …

Mitochondria: from cell death executioners to regulators of cell differentiation

A Kasahara, L Scorrano - Trends in cell biology, 2014 - cell.com
Most, if not all mitochondrial functions, including adenosine-5′-triphosphate (ATP)
production and regulation of apoptosis and Ca 2+ homeostasis, are inextricably linked to …

Cooperative and independent roles of the Drp1 adaptors Mff, MiD49 and MiD51 in mitochondrial fission

LD Osellame, AP Singh, DA Stroud… - Journal of cell …, 2016 - journals.biologists.com
Cytosolic dynamin-related protein 1 (Drp1, also known as DNM1L) is required for both
mitochondrial and peroxisomal fission. Drp1-dependent division of these organelles is …