Urotensin II (UII) is a cyclic neuropeptide that was first isolated from the urophysis of teleost
fish on the basis of its ability to contract the hindgut. Subsequently, UII was characterized in …

Peptides can operate as therapeutic agents that sit within a privileged space between small
molecules and larger biologics. Despite examples of their potential to regulate receptors and …

Allosteric modulators (AMs) of G-protein coupled receptors (GPCRs) are desirable drug
targets because they can produce fewer on-target side effects, improved selectivity, and …

Highlights•Urotensin II is a cyclic undecapeptide involved in cardiovascular
regulation.•Pseudo-irreversible binding to UT receptor could explain urotensin II low …

Visceral sensory neurons encode distinct sensations from healthy organs and initiate pain
states that are resistant to common analgesics. Transcriptome analysis is transforming our …

While the urotensinergic system plays a role in influencing various pathologies, its potential
remains untapped because of the absence of therapeutically effective urotensin II receptor …

In accordance with their common but also divergent physiological actions, human urotensin
II (1) and urotensin II-related peptide (2) could stabilize specific urotensin II receptor (UTR) …

Cyclic azasulfuryl (As) peptide analogs of the urotensin II (UII, 1, H-Glu-Thr-Pro-Asp-c [Cys-
Phe-Trp-Lys-Tyr-Cys]-Val-OH) fragment 4–11 were synthesized to explore the influences of …

The urotensinergic system plays central roles in the physiological regulation of major
mammalian organ systems, including the cardiovascular system. As a matter of fact, this …

Benzotriazepin-2-ones were designed to mimic the suggested bioactive γ-turn conformation
of the Bip-Lys-Tyr tripeptide in Urocontrin ([Bip4] URP), which modulates the urotensin II …