Hypomagnesemia is 10-fold more common in individuals with type 2 diabetes (T2D) than in
the healthy population. Factors that are involved in this high prevalence are low Mg2+ …

Abstract Magnesium (Mg2+) is the most prevalent divalent intracellular cation. As co-factor in
many enzymatic reactions, Mg2+ is essential for protein synthesis, energy production, and …

The CNNM/CorC family proteins are Mg2+ transporters that are widely distributed in all
domains of life. In bacteria, CorC has been implicated in the survival of pathogenic …

CNNM/CorB proteins are a broadly conserved family of integral membrane proteins with
close to 90,000 protein sequences known. They are associated with Mg2+ transport but it is …

The identification of genes causing inherited kidney diseases yielded crucial insights in the
molecular basis of disease and improved our understanding of physiological processes that …

Abstract Magnesium ions (Mg 2+) are the most abundant divalent cations in living organisms
and are essential for various physiological processes, including ATP utilization and the …

Some of the critical mechanisms that mediate chronic kidney disease (CKD) progression are
associated with vascular calcifications, disbalance of mineral metabolism, increased …

Background: In a genome-wide association study of intracranial aneurysms (IA), enrichment
was found between genes associated with IA and genes encoding targets of effective anti …

Extracellular pH is usually maintained around 7.4 in multicellular organisms, and cells are
optimized to proliferate under this condition. Here, we find cells can adapt to a more acidic …

Magnesium is an essential cofactor in many cellular processes, and aberrations in
magnesium homeostasis can have life-threatening consequences. The kidney plays a …