Mechanisms of bacterial tolerance and persistence in the gastrointestinal and respiratory environments

R Trastoy, T Manso, L Fernández-García… - Clinical microbiology …, 2018 - Am Soc Microbiol
Pathogens that infect the gastrointestinal and respiratory tracts are subjected to intense
pressure due to the environmental conditions of the surroundings. This pressure has led to …

Molecular hydrogen metabolism: a widespread trait of pathogenic bacteria and protists

SL Benoit, RJ Maier, RG Sawers… - … and Molecular Biology …, 2020 - Am Soc Microbiol
Pathogenic microorganisms use various mechanisms to conserve energy in host tissues
and environmental reservoirs. One widespread but often overlooked means of energy …

Molecular Hydrogen as an Energy Source for Helicobacter pylori

JW Olson, RJ Maier - Science, 2002 - science.org
The gastric pathogen Helicobacter pylori is known to be able to use molecular hydrogen as
a respiratory substrate when grown in the laboratory. We found that hydrogen is available in …

Microbiota-derived hydrogen fuels Salmonella typhimurium invasion of the gut ecosystem

L Maier, R Vyas, CD Cordova, H Lindsay… - Cell host & …, 2013 - cell.com
The intestinal microbiota features intricate metabolic interactions involving the breakdown
and reuse of host-and diet-derived nutrients. The competition for these resources can limit …

Metallochaperones and metalloregulation in bacteria

DA Capdevila, KA Edmonds… - Essays in biochemistry, 2017 - portlandpress.com
Bacterial transition metal homoeostasis or simply 'metallostasis' describes the process by
which cells control the intracellular availability of functionally required metal cofactors, from …

Metabolism and Genetics of Helicobacter pylori: the Genome Era

A Marais, GL Mendz, SL Hazell… - … and molecular biology …, 1999 - Am Soc Microbiol
The publication of the complete sequence of Helicobacter pylori 26695 in 1997 and more
recently that of strain J99 has provided new insight into the biology of this organism. In this …

Requirement of nickel metabolism proteins HypA and HypB for full activity of both hydrogenase and urease in Helicobacter pylori

JW Olson, NS Mehta, RJ Maier - Molecular microbiology, 2001 - Wiley Online Library
The nickel‐containing enzymes hydrogenase and urease require accessory proteins in
order to incorporate properly the nickel atom (s) into the active sites. The Helicobacter pylori …

Helicobacter pylori Physiology Predicted from Genomic Comparison of Two Strains

P Doig, BL de Jonge, RA Alm, ED Brown… - Microbiology and …, 1999 - Am Soc Microbiol
Helicobacter pylori is a gram-negative bacteria which colonizes the gastric mucosa of
humans and is implicated in a wide range of gastroduodenal diseases. This paper reviews …

Energetics of pathogenic bacteria and opportunities for drug development

GM Cook, C Greening, K Hards, M Berney - Advances in microbial …, 2014 - Elsevier
The emergence and spread of drug-resistant pathogens and our inability to develop new
antimicrobials to overcome resistance has inspired scientists to consider new targets for …

Characterization of Helicobacter pylori Nickel Metabolism Accessory Proteins Needed for Maturation of both Urease and Hydrogenase

N Mehta, JW Olson, RJ Maier - Journal of bacteriology, 2003 - Am Soc Microbiol
Previous studies demonstrated that two accessory proteins, HypA and HypB, play a role in
nickel-dependent maturation of both hydrogenase and urease in Helicobacter pylori. Here …