Despite potent suppression of HIV-1 viral replication in the central nervous system (CNS) by
antiretroviral therapy (ART), between 15% and 60% of HIV-1-infected patients receiving ART …

Neuroinflammation is a complex biological process that plays a significant role in various
brain disorders. Microglia and astrocytes are the key cell types involved in inflammatory …

Iron dysregulation has been implicated in multiple neurodegenerative diseases, including
Parkinson's disease (PD). Iron-loaded microglia are frequently found in affected brain …

The achievement of an HIV cure is dependent on the eradication or permanent silencing of
HIV-latent viral reservoirs, including the understudied central nervous system (CNS) …

Infectious diseases affect individual health and have widespread societal impacts. New ex
vivo models are critical to understand pathogenesis, host response, and features necessary …

Background HIV associated neurocognitive disorders cause significant morbidity and
mortality despite the advent of highly active antiretroviral therapy. A deeper understanding of …

People living with HIV are affected by the chronic consequences of neurocognitive
impairment (NCI) despite antiretroviral therapies that suppress viral replication, improve …

Abstract Three-dimensional (3D) human tissue models/microphysiological systems (eg,
organs-on-chips, organoids, and tissue explants) model HIV and related comorbidities and …

Advancements in human pluripotent stem cell technology offer a unique opportunity for the
neuroimmunology field to study host–virus interactions directly in disease-relevant cells of …

To obtain a comprehensive scenario of T cell profiles and synergistic immune responses, we
performed single-cell RNA sequencing (scRNA-seq) on the peripheral T cells of 14 …