Cellular functions and molecular mechanisms of the ESCRT membrane-scission machinery

L Christ, C Raiborg, EM Wenzel, C Campsteijn… - Trends in biochemical …, 2017 - cell.com
The endosomal sorting complex required for transport (ESCRT) machinery is an assembly of
protein subcomplexes (ESCRT I-III) that cooperate with the ATPase VPS4 to mediate …

Reverse-topology membrane scission by the ESCRT proteins

J Schöneberg, IH Lee, JH Iwasa… - Nature reviews Molecular …, 2017 - nature.com
The narrow membrane necks formed during viral, exosomal and intra-endosomal budding
from membranes, as well as during cytokinesis and related processes, have interiors that …

[HTML][HTML] The ESCRT pathway

WM Henne, NJ Buchkovich, SD Emr - Developmental cell, 2011 - cell.com
Multivesicular bodies (MVBs) deliver cargo destined for degradation to the vacuole or
lysosome. The ESCRT (endosomal sorting complex required for transport) pathway is a key …

Membrane budding and scission by the ESCRT machinery: it's all in the neck

JH Hurley, PI Hanson - Nature reviews Molecular cell biology, 2010 - nature.com
The endosomal sorting complexes required for transport (ESCRTs) catalyse one of the most
unusual membrane remodelling events in cell biology. ESCRT-I and ESCRT-II direct …

Accessory ESCRT‐III proteins are conserved and selective regulators of Rab11a‐exosome formation

PP Marie, SJ Fan, J Mason, A Wells… - Journal of …, 2023 - Wiley Online Library
Exosomes are secreted nanovesicles with potent signalling activity that are initially formed
as intraluminal vesicles (ILVs) in late Rab7‐positive multivesicular endosomes, and also in …

The ESCRT complexes

JH Hurley - Critical reviews in biochemistry and molecular biology, 2010 - Taylor & Francis
The ESCRT machinery consists of the peripheral membrane protein complexes ESCRT-0,-I,-
II,-III, and Vps4–Vta1, and the ALIX homodimer. The ESCRT system is required for …

Vps60 initiates alternative ESCRT-III filaments

AK Pfitzner, H Zivkovic, C Bernat-Silvestre… - Journal of Cell …, 2023 - rupress.org
Endosomal sorting complex required for transport-III (ESCRT-III) participates in essential
cellular functions, from cell division to endosome maturation. The remarkable increase of its …

[HTML][HTML] Ordered assembly of the ESCRT-III complex on endosomes is required to sequester cargo during MVB formation

D Teis, S Saksena, SD Emr - Developmental cell, 2008 - cell.com
The sequential action of the Vps27/HRS complex, ESCRT-I,-II, and-III is required to sort
ubiquitinated transmembrane proteins to the lumen of lysosomes via the multivesicular body …

Membrane Trafficking in the Yeast Saccharomyces cerevisiae Model

S Feyder, JO De Craene, S Bär, DL Bertazzi… - International journal of …, 2015 - mdpi.com
The yeast Saccharomyces cerevisiae is one of the best characterized eukaryotic models.
The secretory pathway was the first trafficking pathway clearly understood mainly thanks to …

Principles of membrane remodeling by dynamic ESCRT-III polymers

AK Pfitzner, JM von Filseck, A Roux - Trends in cell biology, 2021 - cell.com
Endosomal protein complex required for transport-III (ESCRT-III) polymers are involved in
many crucial cellular functions, from cell division to endosome–lysosome dynamics. As a …