The addition to proteins of the negatively charged polymer of ADP-ribose (PAR), which is
synthesized by PAR polymerases (PARPs) from NAD+, is a unique post-translational …

Nicotinamide, the amide form of vitamin B3 (niacin), is changed to its mononucleotide
compound with the enzyme nicotinic acide/nicotinamide adenylyl-transferase, and …

Nicotinamide adenine dinucleotide (NAD+) is an essential electron transporter in
mitochondrial respiration and oxidative phosphorylation. In genomic DNA, NAD+ also …

Summary SIRT1, a NAD+-dependent histone deacetylase, plays crucial roles in multiple
biological processes including gene transcription, cellular metabolism, stress response, and …

The NAD+‐dependent protein deacetylase SIRT1 is linked to cellular survival pathways by
virtue of keeping the tumor suppressor gene p53 and members of the forkhead transcription …

Inappropriate elevation of matrix metalloproteinase‐9 (MMP9) is reported to be involved in
the pathogenesis of chronic obstructive pulmonary disease (COPD). The object of this study …

It has long been understood that many of the same manipulations that increase longevity in
Caenorhabditis elegans also increase resistance to various acute stressors, and vice-versa; …

DNA lesions, constantly produced by endogenous and exogenous sources, activate the
DNA damage response (DDR), which involves detection, signaling and repair of the …

The members of the Sir2 family, or sirtuins, are major regulators of the response to different
types of stress. The members of the family have adapted to increasing complexities …

One of the current problems in medicine research is the development of safe drugs for the
treatment of neurological disorders. Furthermore, there is a close relationship between the …