The microbiota comprises the microorganisms that live in close contact with the host, with
mutual benefit for both counterparts. The contribution of the gut microbiota to the emergence …

Purpose ASCO provisional clinical opinions (PCOs) offer direction to the ASCO membership
after publication or presentation of potential practice-changing data. This PCO addresses …

Data collected from large-scale studies has shown that the incidence of prostate cancer
globally is on the rise, which could be attributed to an overall increase in lifespan. So, the …

Purpose To investigate the changes in testosterone levels and rates of chemical castration
following androgen-deprivation therapy (ADT) with goserelin, triptorelin, and leuprolide …

Androgen deprivation therapy (ADT) is the mainstay palliative treatment for men with locally
advanced and metastatic prostate cancer, and aims to reduce testosterone to levels …

Persistent androgen receptor (AR) signaling is the key driving force behind progression and
development of castration-resistant prostate cancer (CRPC). In many patients, AR COOH …

Testosterone suppression, achieved through orchiectomy or medically induced androgen-
deprivation therapy (ADT), is a standard treatment for men with recurrent and metastatic …

Introduction: Luteinizing hormone-releasing hormone agonists such as leuprolide acetate
(LA) are the most frequently utilized treatment of advanced prostate cancer as the regimen …

Background Serum testosterone measurement is recommended to assess the efficacy of
androgen deprivation therapy (ADT) and to diagnose castration resistance in patients with …

Methods: PubMed and conference proceedings were searched for studies assessing the
impact of low testosterone on clinical outcomes from ADT. The key search terms included …