New modalities for challenging targets in drug discovery

E Valeur, SM Guéret, H Adihou… - Angewandte Chemie …, 2017 - Wiley Online Library
Our ever‐increasing understanding of biological systems is providing a range of exciting
novel biological targets, whose modulation may enable novel therapeutic options for many …

Targeting the incretin/glucagon system with triagonists to treat diabetes

ME Capozzi, RD DiMarchi, MH Tschöp… - Endocrine …, 2018 - academic.oup.com
Abstract Glucagonlike peptide 1 (GLP-1) receptor agonists have been efficacious for the
treatment of type 2 diabetes due to their ability to reduce weight and attenuate …

Emerging hormonal-based combination pharmacotherapies for the treatment of metabolic diseases

C Clemmensen, B Finan, TD Mueller… - Nature Reviews …, 2019 - nature.com
Obesity and its comorbidities, such as type 2 diabetes mellitus and cardiovascular disease,
constitute growing challenges for public health and economies globally. The available …

Peptide therapeutics and the pharmaceutical industry: barriers encountered translating from the laboratory to patients

J Rafferty, H Nagaraj, AP McCloskey… - Current medicinal …, 2016 - ingentaconnect.com
Peptides are receiving increasing interest as clinical therapeutics. These highly tunable
molecules can be tailored to achieve desirable biocompatibility and biodegradability with …

Peptide‐based multi‐agonists: a new paradigm in metabolic pharmacology

SJ Brandt, TD Müller, RD DiMarchi… - Journal of internal …, 2018 - Wiley Online Library
Obesity and its comorbidities, such as type 2 diabetes, are pressing worldwide health
concerns. Available anti‐obesity treatments include weight loss pharmacotherapies and …

Common links between metabolic syndrome and inflammatory bowel disease: current overview and future perspectives

A Michalak, P Mosińska, J Fichna - Pharmacological Reports, 2016 - Elsevier
Metabolic syndrome (MS) features a constellation of central obesity, dyslipidemia, impaired
glucose metabolism and often hypertension joined by insulin resistance and chronic …

Lipidized prolactin-releasing peptide as a new potential tool to treat obesity and type 2 diabetes mellitus: preclinical studies in rodent models

L Mráziková, B Neprašová, A Mengr… - Frontiers in …, 2021 - frontiersin.org
Obesity and type 2 diabetes mellitus (T2DM) are preconditions for the development of
metabolic syndrome, which is reaching pandemic levels worldwide, but there are still only a …

CNS-targeting pharmacological interventions for the metabolic syndrome

K Stemmer, TD Müller, RD DiMarchi… - The Journal of …, 2019 - Am Soc Clin Investig
The metabolic syndrome (MetS) encompasses medical conditions such as obesity,
hyperglycemia, high blood pressure, and dyslipidemia that are major drivers for the ever …

Multiagonist unimolecular peptides for obesity and type 2 diabetes: current advances and future directions

A Hasib - Clinical Medicine Insights: Endocrinology and …, 2020 - journals.sagepub.com
The ever-increasing prevalence of obesity and Type 2 diabetes has necessitated the
development of newer and more effective approaches for achieving efficient glycemic …

Neue Modalitäten für schwierige Zielstrukturen in der Wirkstoffentwicklung

E Valeur, SM Guéret, H Adihou… - Angewandte …, 2017 - Wiley Online Library
Unsere sich stetig erweiternden Kenntnisse über biologische Systeme haben eine Vielzahl
an hoch interessanten neuen biologischen Zielstrukturen aufgedeckt, deren Modulation …