Phase separation is the thermodynamic process that explains how droplets form in
multicomponent fluids. These droplets can provide controlled compartments to localize …

Numerous examples of microbial phase-separated biomolecular condensates have now
been identified following advances in fluorescence imaging and single molecule microscopy …

Chromatin domains and loops are important elements of chromatin structure and dynamics,
but much remains to be learned about their exact biological role and nature. Topological …

Many recent studies of liquid-liquid phase separation in biology focus on phase separation
as a dynamic control mechanism for cellular function, but it can also result in complex …

Proteomic studies have shown that cellular condensates are frequently enriched in diverse
RNA molecules, which is suggestive of mechanistic links between phase separation and …

Molecular mechanisms that dictate chromatin organization in vivo are under active
investigation, and the extent to which intrinsic interactions contribute to this process remains …

The interior of the eukaryotic cell nucleus has a crowded and heterogeneous environment
packed with chromatin polymers, regulatory proteins, and RNA molecules. Chromatin …

Meiosis, a reductional cell division, relies on precise initiation, maturation, and resolution of
crossovers (COs) during prophase I to ensure the accurate segregation of homologous …

By means of a minimal physical model, we investigate the interplay of two phase transitions
at play in chromatin organization:(1) liquid–liquid phase separation within the fluid solvating …

Significance of liquid-liquid phase separation (LLPS)-related genes in breast cancer: a multi-omics
analysis - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage …