TBX3, a member of the ancient and evolutionary conserved T-box transcription factor family,
is a critical developmental regulator of several structures including the heart, mammary …

The contraction pattern of the heart relies on the activation and conduction of the electrical
impulse. Perturbations of cardiac conduction have been associated with congenital and …

In addition to their critical roles in embryonic development, cell fate decision, and
differentiation, members of Sox (Sry-related high-mobility group box) family of transcription …

The overexpression of SOX4 in various kinds of cancer cells was associated with poor
prognosis for patients. The role of SOX4 in angiogenesis and tumor microenvironment …

As the cerebral cortex forms, specialized molecular cascades direct the expansion of
progenitor pools, the differentiation of neurons, or the maturation of discrete neuronal …

Tbx2 and Tbx3 are two highly related members of the T-box transcription factor gene family
that regulate patterning and differentiation of a number of tissue rudiments in the mouse …

Congenital heart defects represent the most common human birth defects and are often life-
threatening. Frequently, they are caused by abnormalities of the outflow tract whose …

The components of the cardiac conduction system, responsible for coordinated activation of
the heart chambers, are well defined and their cells differ in gene expression profile and …

TBX3 is a member of the T-box family of transcription factors with critical roles in
development, oncogenesis, cell fate, and tissue homeostasis. TBX3 mutations in humans …

The closely related T-box transcription factors TBX2 and TBX3 are frequently overexpressed
in melanoma and various types of human cancers, in particular, breast cancer. The …