Toward merging untargeted and targeted methods in mass spectrometry-based metabolomics and lipidomics

T Cajka, O Fiehn - Analytical chemistry, 2016 - ACS Publications
Advances in mass spectrometry (MS) and data processing have led to discoveries in
regulation of cellular metabolism by using metabolomics and lipidomics approaches. 1, 2 …

Nutrimetabolomics: an integrative action for metabolomic analyses in human nutritional studies

MM Ulaszewska, CH Weinert… - Molecular nutrition & …, 2019 - Wiley Online Library
The life sciences are currently being transformed by an unprecedented wave of
developments in molecular analysis, which include important advances in instrumental …

[HTML][HTML] Toward building mass spectrometry-based metabolomics and lipidomics atlases for biological and clinical research

S Rakusanova, O Fiehn, T Cajka - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Current metabolomics and lipidomics studies are limited in the number of examined
matrices, the breadth and scope of methods, reporting the number of metabolites, and data …

Longitudinal metabolomics of human plasma reveals prognostic markers of COVID-19 disease severity

M Sindelar, E Stancliffe, M Schwaiger-Haber… - Cell Reports …, 2021 - cell.com
There is an urgent need to identify which COVID-19 patients will develop life-threatening
illness so that medical resources can be optimally allocated and rapid treatment can be …

Metabolomics for personalized medicine: the input of analytical chemistry from biomarker discovery to point-of-care tests

FA Castelli, G Rosati, C Moguet, C Fuentes… - Analytical and …, 2022 - Springer
Metabolomics refers to the large-scale detection, quantification, and analysis of small
molecules (metabolites) in biological media. Although metabolomics, alone or combined …

Reference standardization for quantification and harmonization of large-scale metabolomics

KH Liu, M Nellis, K Uppal, C Ma, VL Tran… - Analytical …, 2020 - ACS Publications
Reference standardization was developed to address quantification and harmonization
challenges for high-resolution metabolomics (HRM) data collected across different studies …

statTarget: A streamlined tool for signal drift correction and interpretations of quantitative mass spectrometry-based omics data

H Luan, F Ji, Y Chen, Z Cai - Analytica chimica acta, 2018 - Elsevier
Large-scale quantitative mass spectrometry-based metabolomics and proteomics study
requires the long-term analysis of multiple batches of biological samples, which often …

Improved batch correction in untargeted MS-based metabolomics

R Wehrens, JA Hageman, F van Eeuwijk, R Kooke… - Metabolomics, 2016 - Springer
Introduction Batch effects in large untargeted metabolomics experiments are almost
unavoidable, especially when sensitive detection techniques like mass spectrometry (MS) …

Methods that remove batch effects while retaining group differences may lead to exaggerated confidence in downstream analyses

V Nygaard, EA Rødland, E Hovig - Biostatistics, 2016 - academic.oup.com
Removal of, or adjustment for, batch effects or center differences is generally required when
such effects are present in data. In particular, when preparing microarray gene expression …

Recent advances in proteomics and metabolomics in plants

S Yan, R Bhawal, Z Yin, TW Thannhauser… - Molecular Horticulture, 2022 - Springer
Over the past decade, systems biology and plant-omics have increasingly become the main
stream in plant biology research. New developments in mass spectrometry and …