Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

BACKGROUND Oocyte aging has significant clinical consequences, and yet no treatment
exists to address the age-related decline in oocyte quality. The lack of progress in the …

Oxidative stress has been implicated in various aspects of aging, but the role of oxidative
stress in ovarian aging remains unclear. Our previous studies have shown that the initiation …

We report herein a novel mechanism, unraveled by proteomics and validated by in vitro and
in vivo studies, of the aberrant aging-associated upregulation of ovarian transferrin and …

The development of a competent oocyte intimately depends on the maintenance of
energetic homeostasis in the ovarian and follicular microenvironment. On this basis, it is very …

Oocyte quality has long been considered as a main limiting factor for in vitro fertilization
(IVF). In the past decade, extensive observations demonstrated that the mitochondrion plays …

Sperm‐induced Ca2+ rise is critical for driving oocyte activation and subsequent embryonic
development, but little is known about how lasting Ca2+ oscillations are regulated. Here it is …

Background Caloric restriction (CR) counters deleterious effects of aging and, for most
mouse genotypes, increases mean and maximum lifespan. Previous analyses of microarray …

The subcortical maternal complex (SCMC) is a multiprotein complex uniquely expressed in
mammalian oocytes and early embryos, essential for zygote progression beyond the first …

The reproductive system of human female exhibits a much faster rate of aging than other
body systems. Ovarian aging is thought to be dominated by a gradual decreasing numbers …