The immune system plays a critical role in protecting hosts from the invasion of organisms.
CD4 T cells, as a key component of the immune system, are central in orchestrating adaptive …

Immunometabolism has emerged as a major mechanism central to adaptive and innate
immune regulation. From early observations that inflammatory cytokines were induced in …

Introduction Breast cancer (BRCA) has the highest incidence among female malignancies,
and the prognosis for these patients remains poor. Materials and Methods In this study, core …

Regulatory T cells (Treg) are well-known for their immune regulatory potential and are
essential for maintaining immune homeostasis. The rationale of Treg-based immunotherapy …

Regulatory T cells (Tregs) are engaged in maintaining immune homeostasis and preventing
autoimmunity. Treg cells include thymic Treg cells and peripheral Treg cells, both of which …

T regulatory (Treg) cells were discovered more than 20 years ago and have remained a
topic of intense investigation by immunologists. The initial doubts about their existence were …

Suppressive regulatory T cell (Treg) differentiation is controlled by diverse immunometabolic
signaling pathways and intracellular metabolites. Here we show that cell-permeable α …

Abstract CD4+ CD25+ regulatory T cells (Tregs) are a class of CD4+ T cells with
immunosuppressive functions that play a critical role in maintaining immune homeostasis …

Neuroinflammatory conditions such as multiple sclerosis (MS) are initiated by pathogenic
immune cells invading the central nervous system (CNS). Autoreactive CD4+ T helper cells …

Regulatory T cells (Tregs) are instrumental in maintaining immune tolerance and preventing
destructive autoimmunity, but how heterogeneous Treg populations are established remains …