Isoniazid (INH) was the first synthesized drug that mediated bactericidal killing of the
bacterium Mycobacterium tuberculosis, a major clinical breakthrough. To this day, INH …

Background Treatment of drug susceptible tuberculosis (DS-TB) requires regimens
containing first line drugs (FLDs') whereas drug resistant tuberculosis (DR-TB) are treated …

Background Previously treated tuberculosis (TB) patients are a widely reported risk factor for
multidrug-resistant tuberculosis. Identifying patients' problems during treatment is necessary …

Toll-like receptors play a vital role in cell-mediated immunity, which is crucial for the immune
system's defense against pathogens and maintenance of homeostasis. The interaction …

Background Mental health disorders, social stress, and poor health-related quality of life are
commonly reported among people with tuberculosis (TB). We conducted a systematic review …

Tuberculosis (TB), one of the deadliest contagious diseases, is a major concern worldwide.
Long-term treatment, a high pill burden, limited compliance, and strict administration …

Background: Multidrug-resistant tuberculosis (MDR-TB) is a growing public health problem.
Treatment regimens used against MDR-TB are costly, prolonged, and associated with more …

About half of the world's population and 80% of the world's biodiversity can be found in the
tropics. Many diseases are specific to the tropics, with at least 41 diseases caused by …

Rapid, sensitive, accurate and portable diagnostics are a mainstay of modern medicine.
Tuberculosis is a disease that has been with us since time immemorial and, despite the fact …

Introduction: Antiretroviral and anti-tuberculosis (TB) drugs are often co-administered in
people living with HIV (PLWH). Early initiation of antiretroviral therapy (ART) during TB …