Reproduction is controlled by the hypothalamic-pituitary-gonadal (HPG) axis. Gonadotropin-
releasing hormone (GnRH) neurons play a central role in this axis through production of …

This review presents a comprehensive discussion of the clinical condition of delayed
puberty, a common presentation to the pediatric endocrinologist, which may present both …

Reelin is an extracellular matrix protein with various functions during development and in
the mature brain. It activates different signaling cascades in target cells, one of which is the …

We outline a unified model for inside-out layering of the neocortex, hinging on a new
interpretation for the effects of Reelin on neuronal migrations. The effects of Reelin on …

Gonadotrophin‐releasing hormone‐1 (GnRH‐1) is essential for mammalian reproduction,
controlling release of gonadotrophins from the anterior pituitary. GnRH‐1 neurones migrate …

GnRH neurons follow a carefully orchestrated journey from their birth in the olfactory
placode area. Initially, they migrate along with the vomeronasal nerve into the brain at the …

Early or late pubertal onset affects up to 5% of adolescents and is associated with adverse
health and psychosocial outcomes. Self‐limited delayed puberty (DP) segregates …

Temperature dependent sex determination (TSD) is the process by which the environmental
temperature experienced during embryogenesis influences the sex of an organism, as in the …

Reelin is a large secreted glycoprotein that is essential for correct neuronal positioning
during neurodevelopment and is important for synaptic plasticity in the mature brain …

Individuals with an inherited deficiency in gonadotropin-releasing hormone (GnRH) have
impaired sexual reproduction. Previous genetic linkage studies and sequencing of plausible …