Cellular senescence is implicated in physiological and pathological processes spanning
development, wound healing, age-related decline in organ functions and cancer. Here, we …

Cellular senescence is a state of stable cell-cycle arrest with secretory features in response
to cellular stress. Historically, it has been considered as an endogenous evolutionary …

Simple Summary Senescence is a form of cell cycle arrest induced by stresses such as DNA
damage and oncogenes and therefore constitutes a crucial barrier against cancer …

The study of cell senescence is a burgeoning field. Senescent cells can modify the cellular
microenvironment through the secretion of a plethora of biologically active products referred …

Purpose: Bioinformatics analysis followed by in vivo studies in patient-derived xenograft
(PDX) models were used to identify and validate CDK 4/6 inhibition as an effective …

Cellular senescence in cancer development is known to have tumor‐suppressive and tumor‐
promoting roles. Recent studies have revealed numerous molecular mechanisms of …

Medulloblastoma (MB) is a neoplasm linked to dysregulated cerebellar development.
Previously, we demonstrated that the Sonic Hedgehog (SHH) subgroup grows …

ABSTRACT Patched 1 (PTCH1) is the primary receptor for the sonic hedgehog (SHH) ligand
and negatively regulates SHH signalling, an essential pathway in human embryogenesis …

Tumor cells are characterized by unlimited proliferation and perturbed differentiation. Using
single-cell RNA sequencing, we demonstrate that tumor cells in medulloblastoma (MB) …

Simple Summary The current treatment options for medulloblastoma, the most common
malignant childhood brain cancer, are associated with many negative side effects and …