Forkhead box (Fox) transcription factors are evolutionarily conserved in organisms ranging
from yeast to humans. They regulate diverse biological processes both during development …

Epigenetic dysregulation may influence disease progression. Here we explore whether
epigenetic alterations in human pancreatic islets impact insulin secretion and type 2 …

Decreasing glucagon action lowers the blood glucose and may be useful therapeutically for
diabetes. However, interrupted glucagon signaling leads to α cell proliferation. To identify …

Cyclin-dependent kinases (CDKs) and their inhibitors (CDKIs) play pivotal roles in the
regulation of the cell cycle. As a result of these functions, it may be extrapolated that they are …

The incidence of type 1 diabetes (T1D) has substantially increased over the past decade,
suggesting a role for non-genetic factors such as epigenetic mechanisms in disease …

Background Neurodevelopment is orchestrated by a wide range of genes, and the genetic
causes of neurodevelopmental disorders are thus heterogeneous. We applied whole exome …

Osteosarcoma has a poor prognosis, and the poor understanding of the genetic drivers of
osteosarcoma hinders further improvement in therapeutic approaches. Transcription factor …

Background Four patients from three Norwegian families presented with a common skin
phenotype of warts, molluscum contagiosum, and dermatitis since early childhood, and …

The transcription factor NFATC2 induces β cell proliferation in mouse and human islets.
However, the genomic targets that mediate these effects have not been identified. We …

The biomimetic pancreatic microenvironment improves the differentiation efficiency and
function of human embryonic stem cell-derived β-cells (S C-β cells). Thus, a laminin subunit …