[HTML][HTML] A faecal microbiota signature with high specificity for pancreatic cancer

E Kartal, TSB Schmidt, E Molina-Montes… - Gut, 2022 - gut.bmj.com
Background Recent evidence suggests a role for the microbiome in pancreatic ductal
adenocarcinoma (PDAC) aetiology and progression. Objective To explore the faecal and …

Combinatorial, additive and dose-dependent drug–microbiome associations

SK Forslund, R Chakaroun… - Nature, 2021 - nature.com
During the transition from a healthy state to cardiometabolic disease, patients become
heavily medicated, which leads to an increasingly aberrant gut microbiome and serum …

Towards the biogeography of prokaryotic genes

LP Coelho, R Alves, ÁR Del Río, PN Myers… - Nature, 2022 - nature.com
Microbial genes encode the majority of the functional repertoire of life on earth. However,
despite increasing efforts in metagenomic sequencing of various habitats,–, little is known …

Drivers and determinants of strain dynamics following fecal microbiota transplantation

TSB Schmidt, SS Li, OM Maistrenko, W Akanni… - Nature medicine, 2022 - nature.com
Fecal microbiota transplantation (FMT) is a therapeutic intervention for inflammatory
diseases of the gastrointestinal tract, but its clinical mode of action and subsequent …

A deep siamese neural network improves metagenome-assembled genomes in microbiome datasets across different environments

S Pan, C Zhu, XM Zhao, LP Coelho - Nature communications, 2022 - nature.com
Metagenomic binning is the step in building metagenome-assembled genomes (MAGs)
when sequences predicted to originate from the same genome are automatically grouped …

Extensive transmission of microbes along the gastrointestinal tract

TSB Schmidt, MR Hayward, LP Coelho, SS Li… - elife, 2019 - elifesciences.org
The gastrointestinal tract is abundantly colonized by microbes, yet the translocation of oral
species to the intestine is considered a rare aberrant event, and a hallmark of disease. By …

<? mode longmeta?> SPIRE: a Searchable, Planetary-scale mIcrobiome REsource

TSB Schmidt, A Fullam, P Ferretti, A Orakov… - Nucleic Acids …, 2024 - academic.oup.com
Meta'omic data on microbial diversity and function accrue exponentially in public
repositories, but derived information is often siloed according to data type, study or sampled …

Recent advances of machine learning applications in human gut microbiota study: from observational analysis toward causal inference and clinical intervention

F Salim, S Mizutani, M Zolfo, T Yamada - Current Opinion in Biotechnology, 2023 - Elsevier
Highlights•ML facilitates the detection of disease-associated microbial features.•Open data
repository and tool development improves study reproducibility.•Recent methods integrate …

Microbiome meta-analysis and cross-disease comparison enabled by the SIAMCAT machine learning toolbox

J Wirbel, K Zych, M Essex, N Karcher, E Kartal… - Genome biology, 2021 - Springer
The human microbiome is increasingly mined for diagnostic and therapeutic biomarkers
using machine learning (ML). However, metagenomics-specific software is scarce, and …

Gut microbiome and atrial fibrillation—results from a large population-based study

J Palmu, CS Börschel, A Ortega-Alonso, L Markó… - …, 2023 - thelancet.com
Background Atrial fibrillation (AF) is an important heart rhythm disorder in aging populations.
The gut microbiome composition has been previously related to cardiovascular disease risk …