The growing prevalence of antimicrobial resistance (AMR) has brought with it a continual
increase in the numbers of deaths from multidrug-resistant (MDR) infections. Since the …

Antibacterial resistance is a severe threat to modern medicine and human health. To stay
ahead of constantly-evolving bacteria we need to expand our arsenal of effective antibiotics …

The genesis of cell-penetrating peptide research (CPP; also known as prote/peptide
transduction domains, PTD, or Trojan peptides) was born from the publication of two parallel …

Peptide nucleic acid (PNA) is a nucleic acid mimic with high specificity and binding affinity to
natural DNA or RNA, as well as resistance to enzymatic degradation. PNA sequences can …

Nitrile‐aminothiol conjugation (NATC) stands out as a promising biocompatible ligation
technique due to its high chemo‐selectivity. Herein we investigated the reactivity and …

The gradual depletion of antibiotic discovery pipeline makes the antibiotic resistance a
difficult clinical problem and a global health emergency. The membrane-active antimicrobial …

Peptide-based antibiotics (PBAs), including antimicrobial peptides (AMPs) and their
synthetic mimics, have received significant interest due to their diverse and unique …

Bacteria secrete various iron-chelators (siderophores), which scavenge Fe3+ from the
environment, bind it with high affinity, and retrieve it inside the cell. After the Fe3+ uptake …

Antisense oligonucleotides have been developed as therapeutic compounds, with peptide
nucleic acid (PNA) emerging as a promising nucleic acid mimic for antimicrobial …

The functionalization of proteins with DNA through the formation of covalent bonds enables
a wide range of biotechnology advancements. For example, single-molecule analytical …