Aminoglycoside antibiotics are used as prophylaxis, or urgent treatment, for many life-
threatening bacterial infections, including tuberculosis, sepsis, respiratory infections in cystic …

Despite a prevalence greater than cancer or diabetes, there are no currently approved drugs
for the treatment of hearing loss. Research over the past two decades has led to a vastly …

Hernandezine (Her) is a bisbenzylisoquinoline alkaloid extracted from the traditional
Chinese herbal medicine Thalictrum glandulosissimum. Evidence shows that Her is a …

Aminoglycoside (AG) antibiotics are widely used to prevent life-threatening infections, and
cisplatin is used in the treatment of various cancers, but both are ototoxic and result in loss of …

To identify small molecules that shield mammalian sensory hair cells from the ototoxic side
effects of aminoglycoside antibiotics, 10,240 compounds were initially screened in zebrafish …

Hair cells are the mechanosensory receptors of the inner ear and can be damaged by noise,
aging, and ototoxic drugs. This damage often results in permanent sensorineural hearing …

Aminoglycoside antibiotics are widely used for the treatment of life-threatening bacterial
infections, but cause permanent hearing loss in a substantial proportion of treated patients …

Black pigment cells, melanocytes, arise early during development from multipotent neural
crest cells. Melanocytes protect human skin from DNA damaging sunrays and provide color …

Four major types of biomacromolecules are nucleic acids (DNAs and RNAs), proteins, lipids,
and glycans. Only carbohydrates or glycans are a universal existence in all types of the …

Aim: The present review aimed to consolidate and analyze the recent information about the
use of zebrafish in studies concerning cisplatin-induced ototoxicity and otoprotection …