Two-component systems (TCSs) are a ubiquitous family of signal transduction pathways that
enable bacteria to sense and respond to physical, chemical, and biological stimuli outside …

Two‐component regulatory systems (2CRSs) are key players in bacterial responses to
changing environments (1, 2). These systems act to integrate multiple stimuli into …

Light-switchable proteins enable unparalleled control of molecular biological processes in
live organisms. Previously, we have engineered red/far-red and green/red photoreversible …

Two-component systems (TCSs) are the largest family of multi-step signal transduction
pathways and valuable sensors for synthetic biology. However, most TCSs remain …

Nucleotide-activated effector deployment, prototyped by interferon-dependent immunity, is a
common mechanistic theme shared by immune systems of several animals and prokaryotes …

The PhoPR two-component system is essential for virulence in Mycobacterium tuberculosis
where it controls expression of approximately 2% of the genes, including those for the ESX-1 …

Mycobacterium tuberculosis has evolved from a Mycobacterium canettii‐like progenitor pool
into one of the most successful and widespread human pathogens. The pathogenicity of M …

Different members of the Mycobacterium genus have evolved to cause tuberculosis in
diverse human populations and in a variety of animal species. Our cumulative knowledge of …

With rising antibiotic resistance at alarming rates in S. aureus, a major human pathogen, it is
important to identify targets for new antimicrobial therapies. A number of two-component …

Highlights•The human gut microbiota interacts extensively with the host and is intricately
linked to health and disease.•Non-invasive tools to monitor microbial states and disease …