The establishment and utilization of preclinical animal models constitute a pivotal aspect
across all facets of cancer research, indispensably contributing to the comprehension of …

Toxicological test methods generate raw data and provide instructions on how to use these
to determine a final outcome such as a classification of test compounds as hits or non-hits …

Per-and polyfluoroalkyl substances (PFAS) are synthetic chemicals known for their
persistence and bioaccumulation, leading to widespread environmental contamination …

Brazil stands as the world's leading coffee producer, where the extensive use of pesticides is
economically critical yet poses health and environmental risks due to their non-selective …

Per-and poly-fluoroalkyl substances (PFAS) are synthetic chemicals widely used in
commercial products. PFAS are a global concern due to their persistence in the environment …

Exposure to various chemicals found in the environment and in the context of drug
development can cause acute toxicity. To provide an alternative to in vivo animal toxicity …

Widespread wastewater pollution is one of the biggest challenges threatening the ecological
health of rivers. It is crucial to identify the toxic changes of effluents after entering urban …

Nonspecific reactive chemicals often interfere with the interpretation of high-throughput
assay results because of their promiscuity and/or cytotoxicity. Using a high-throughput assay …

All‐trans retinoic acid (atRA) is an endogenous ligand of the retinoic acid receptors, which
heterodimerize with retinoid X receptors. AtRA is generated in tissues from vitamin A (retinol) …

Despite significant improvements in methodologies behind the development of new
anticancer therapies, the path from early-stage drug development through preclinical and …