The functionalization of molecules by cleaving inert carbon–carbon single bonds is
regarded as a great synthetic challenge due to their inherent stability. In recent years …

The cleavage of C–C bonds has been a great challenge owing to their thermodynamic and
kinetic stability. To date, the progress made in this area has mainly relied on the reaction of …

The metal-catalyzed asymmetric conjugate addition (ACA) reaction has emerged as a
general and powerful approach for the construction of optically active compounds and is …

A novel enantioselective copper-catalyzed trifluoromethylalkynylation of styrenes,
proceeding through a radical relay process, is described herein, which affords structurally …

Catalytic enantioselective functionalization of cyclobutenes constitutes a general and
modular strategy for construction of enantioenriched complex cyclobutanes bearing multiple …

Quaternary carbon stereocenters are common structural motifs in organic synthesis. The
construction of these stereocenters in a catalytic and enantioselective manner remains a …

The highly efficient copper-catalyzed enantioselective alkynylation of the remote C (sp3)–H
bond on linear primary sulfonamides is presented here using a radical relay strategy. The …

A convenient and efficient vicinal oxyalkynylation/aminoalkynylation of internal unactivated
alkenes is achieved by means of a Cu-catalyzed radical cascade reaction of unsaturated …

Catalytic enantioselective functionalization of unactivated 1, 1‐disubstituted alkenes is
challenging due to the difficulty to discriminate the enantiotopic faces. Enantioselective …

A rhodium-catalyzed highly regio-and enantioselective hydroalkynylation, generating cis-
hydrobenzofuranone-tethered enynes has been developed. The reaction proceeds with a …