Organoids are self-organizing, expanding 3D cultures derived from stem cells. Using tissue
derived from patients, these miniaturized models recapitulate various aspects of patient …

Cancer is a major public health problem worldwide. Gastrointestinal cancers account for
approximately one-third of the total global cancer incidence and mortality. Historically, the …

Adult stem cell–based organoid technology is a versatile tool for the generation and long-
term maintenance of near-native 3D epithelial tissues in vitro. The generation of cancer …

Patient-derived organoids (PDO) are a new biomedical research model that can reconstruct
phenotypic and genetic characteristics of the original tissue and are useful for research on …

Patient-derived cancer organoids have taken a prominent role in pre-clinical and
translational research and have been generated for most common solid tumors. Cancer …

Cancer comprises a collection of highly proliferative and heterogeneous cells growing within
an adaptive and evolving tumour microenvironment. Cancer survival rates have significantly …

We are entering an era of medicine where increasingly sophisticated data will be obtained
from patients to determine proper diagnosis, predict outcomes and direct therapies. We …

Abstract Multiple three-dimensional (3D) tumour organoid models assisted by multi-omics
and Artificial Intelligence (AI) have contributed greatly to preclinical drug development and …

Organoid technology has rapidly transformed basic biomedical research and contributed to
significant discoveries in the last decade. With the application of protocols to generate …

Glioblastoma is the most common brain malignant tumor in the adult population, and
immunotherapy is playing an increasingly central role in the treatment of many cancers …