DNA methylation in cancer: too much, but also too little
M Ehrlich - Oncogene, 2002 - nature.com
Cancer-associated DNA hypomethylation is as prevalent as cancer-linked hypermethylation,
but these two types of epigenetic abnormalities usually seem to affect different DNA …
but these two types of epigenetic abnormalities usually seem to affect different DNA …
Cancer immunotherapy: a future paradigm shift in the treatment of non–small cell lung cancer
VK Anagnostou, JR Brahmer - Clinical Cancer Research, 2015 - AACR
Emerging evidence on the role of the antitumor activity of the immune system has generated
great interest in immunotherapy even for tumors that were historically considered as …
great interest in immunotherapy even for tumors that were historically considered as …
Degradation of AMPK by a cancer-specific ubiquitin ligase
AMP-activated protein kinase (AMPK) is a master sensor and regulator of cellular energy
status. Upon metabolic stress, AMPK suppresses anabolic and promotes catabolic …
status. Upon metabolic stress, AMPK suppresses anabolic and promotes catabolic …
Cause and consequence of cancer/testis antigen activation in cancer
AW Whitehurst - Annual review of pharmacology and toxicology, 2014 - annualreviews.org
Tumor cells frequently exhibit widespread epigenetic aberrations that significantly alter the
repertoire of expressed proteins. In particular, it has been known for nearly 25 years that …
repertoire of expressed proteins. In particular, it has been known for nearly 25 years that …
DNA methylation in lung cancer: mechanisms and associations with histological subtypes, molecular alterations, and major epidemiological factors
PH Hoang, MT Landi - Cancers, 2022 - mdpi.com
Simple Summary Aberrant DNA methylation is associated with multiple malignancies,
including lung cancer. Differences in methylation patterns have been observed across lung …
including lung cancer. Differences in methylation patterns have been observed across lung …
Clinical epigenetics of lung cancer
SM Langevin, KT Kelsey - Translating Epigenetics to the Clinic, 2017 - Elsevier
In 2015, lung cancer accounted for an estimated 221,200 new cancer diagnoses and
158,040 deaths in the United States, with the majority being attributable to cigarette …
158,040 deaths in the United States, with the majority being attributable to cigarette …
Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma
N Sato, A Maitra, N Fukushima, NT Van Heek… - Cancer research, 2003 - AACR
To investigate the relationship between DNA hypomethylation and gene overexpression in
pancreatic cancer, we analyzed the methylation status of a subset of 18 genes previously …
pancreatic cancer, we analyzed the methylation status of a subset of 18 genes previously …
DNA methylation analysis: a powerful new tool for lung cancer diagnosis
JA Tsou, JA Hagen, CL Carpenter, IA Laird-Offringa - Oncogene, 2002 - nature.com
Carcinoma of the lung is the most common cause of cancer death worldwide. The estimated
5-year survival ranges from 6–16%, depending on the cell type. The best opportunity for …
5-year survival ranges from 6–16%, depending on the cell type. The best opportunity for …
MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents
M Monte, M Simonatto, LY Peche… - Proceedings of the …, 2006 - National Acad Sciences
The MAGE gene family is characterized by a conserved domain (MAGE Homology Domain).
A subset of highly homologous MAGE genes (group A; MAGE-A) belong to the chromosome …
A subset of highly homologous MAGE genes (group A; MAGE-A) belong to the chromosome …
A comprehensive guide to the MAGE family of ubiquitin ligases
AK Lee, PR Potts - Journal of molecular biology, 2017 - Elsevier
Melanoma antigen (MAGE) genes are conserved in all eukaryotes and encode for proteins
sharing a common MAGE homology domain. Although only a single MAGE gene exists in …
sharing a common MAGE homology domain. Although only a single MAGE gene exists in …