Down syndrome: Cognitive and behavioral functioning across the lifespan

J Grieco, M Pulsifer, K Seligsohn… - American Journal of …, 2015 - Wiley Online Library
Individuals with Down syndrome (DS) commonly possess unique neurocognitive and
neurobehavioral profiles that emerge within specific developmental periods. These profiles …

Cognitive deficits and associated neurological complications in individuals with Down's syndrome

IT Lott, M Dierssen - The Lancet Neurology, 2010 - thelancet.com
Improvements in medical interventions for people with Down's syndrome have led to a
substantial increase in their longevity. Diagnosis and treatment of neurological …

Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8

ZC Hartman, GM Poage, P Den Hollander, A Tsimelzon… - Cancer research, 2013 - AACR
Triple-negative breast cancers (TNBC) are aggressive with no effective targeted therapies. A
combined database analysis identified 32 inflammation-related genes differentially …

Behavioral phenotype of individuals with Down syndrome

RS Chapman, LJ Hesketh - Mental retardation and …, 2000 - Wiley Online Library
Evidence is reviewed for a developmentally‐emerging behavioral phenotype in individuals
with Down syndrome that includes significant delay in nonverbal cognitive development …

The neuropsychology of Down syndrome: evidence for hippocampal dysfunction

BF Pennington, J Moon, J Edgin, J Stedron… - Child …, 2003 - Wiley Online Library
This study tested prefrontal and hippocampal functions in a sample of 28 school–aged (M=
14.7 years, SD= 2.7) individuals with Down syndrome (DS) compared with 28 (M= 4.9 years …

[图书][B] Visuo-spatial working memory and individual differences

C Cornoldi, T Vecchi - 2004 - taylorfrancis.com
In this timely and comprehensive text, Cesare Cornoldi and Tomaso Vecchi describe their
recently developed experimental approach to the investigation of visuo-spatial cognition …

Neuroanatomy of Down's syndrome: a high-resolution MRI study

JD Pinter, S Eliez, JE Schmitt… - American Journal of …, 2001 - Am Psychiatric Assoc
OBJECTIVE: Down's syndrome, the most common genetic cause of mental retardation,
results in characteristic physical and neuropsychological findings, including mental …

Down syndrome: cognitive phenotype

W Silverman - Mental retardation and developmental …, 2007 - Wiley Online Library
Down syndrome is the most prevalent cause of intellectual impairment associated with a
genetic anomaly, in this case, trisomy of chromosome 21. It affects both physical and …

Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome

AM Kleschevnikov, PV Belichenko… - Journal of …, 2004 - Soc Neuroscience
Although many genetic disorders are characterized by cognitive failure during development,
there is little insight into the neurobiological basis for the abnormalities. Down syndrome …

Motor development and neuropsychological patterns in persons with Down syndrome

S Vicari - Behavior genetics, 2006 - Springer
Neuropsychological research has permitted defining specific cognitive profiles among
individuals with mental retardation (MR) of different etiology. Namely, the cognitive profile of …