Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga… - Signal transduction and …, 2022 - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …

Microbiome–microglia connections via the gut–brain axis

R Abdel-Haq, JCM Schlachetzki, CK Glass… - Journal of Experimental …, 2019 - rupress.org
Microglia, the resident immune cells in the brain, are essential for modulating neurogenesis,
influencing synaptic remodeling, and regulating neuroinflammation by surveying the brain …

[HTML][HTML] Plasma and fecal metabolite profiles in autism spectrum disorder

BD Needham, MD Adame, G Serena, DR Rose… - Biological …, 2021 - Elsevier
Background Autism spectrum disorder (ASD) is a neurodevelopmental condition with
hallmark behavioral manifestations including impaired social communication and restricted …

Priming for life: early life nutrition and the microbiota-gut-brain axis

A Ratsika, MC Codagnone, S O'Mahony, C Stanton… - Nutrients, 2021 - mdpi.com
Microbes colonize the human body during the first moments of life and coexist with the host
throughout the lifespan. Intestinal microbiota and their metabolites aid in the programming of …

Probiotics for gastrointestinal symptoms and quality of life in autism: a placebo-controlled pilot trial

LE Arnold, RA Luna, K Williams, J Chan… - Journal of child and …, 2019 - liebertpub.com
Objective: A randomized pilot trial of gastrointestinal (GI) symptoms targeting probiotic for
quality of life in autism spectrum disorder (ASD). Methods: Thirteen children, 3–12 years of …

The brain-gut-microbiome system: pathways and implications for autism spectrum disorder

MA Chernikova, GD Flores, E Kilroy, JS Labus… - Nutrients, 2021 - mdpi.com
Gastrointestinal dysfunction is one of the most prevalent physiological symptoms of autism
spectrum disorder (ASD). A growing body of largely preclinical research suggests that …

Alteration of gut microbiota: new strategy for treating autism spectrum disorder

J Liu, Z Gao, C Liu, T Liu, J Gao, Y Cai… - Frontiers in cell and …, 2022 - frontiersin.org
Autism spectrum disorder (ASD) is defined as a complex heterogeneous disorder and
characterized by stereotyped behavior and deficits in communication and social interactions …

[HTML][HTML] Emerging mechanisms of valproic acid-induced neurotoxic events in autism and its implications for pharmacological treatment

A Taleb, W Lin, X Xu, G Zhang, QG Zhou… - Biomedicine & …, 2021 - Elsevier
Autism spectrum disorder (ASD) is a sort of mental disorder marked by deficits in cognitive
and communication abilities. To date no effective cure for this pernicious disease has been …

Germ-free animal experiments in the gut microbiota studies

T Uzbay - Current Opinion in Pharmacology, 2019 - Elsevier
Gut microbiota has a crucial role in the maintenance of health. Increasing evidence suggests
that changes or disturbances in gut microbiota may be associated with various diseases …

Conserving the holobiont

AJR Carthey, DT Blumstein, RV Gallagher… - Functional …, 2020 - Wiley Online Library
Organismal biology has undergone a dramatic paradigm shift in the last decade. The
realization that host cells and genes are outnumbered by symbiotic microbial cells and their …