[HTML][HTML] Effective tools for RNA-derived therapeutics: siRNA interference or miRNA mimicry
P Wang, Y Zhou, AM Richards - Theranostics, 2021 - ncbi.nlm.nih.gov
The approval of the first small interfering RNA (siRNA) drug Patisiran by FDA in 2018 marks
a new era of RNA interference (RNAi) therapeutics. MicroRNAs (miRNA), an important post …
a new era of RNA interference (RNAi) therapeutics. MicroRNAs (miRNA), an important post …
An RNA toolbox for cancer immunotherapy
Cancer immunotherapy has revolutionized oncology practice. However, current protein and
cell therapy tools used in cancer immunotherapy are far from perfect, and there is room for …
cell therapy tools used in cancer immunotherapy are far from perfect, and there is room for …
Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein
T Hashimoto, DD Horikawa, Y Saito… - Nature …, 2016 - nature.com
Tardigrades, also known as water bears, are small aquatic animals. Some tardigrade
species tolerate almost complete dehydration and exhibit extraordinary tolerance to various …
species tolerate almost complete dehydration and exhibit extraordinary tolerance to various …
[HTML][HTML] The neuropeptide Tac2 controls a distributed brain state induced by chronic social isolation stress
Chronic social isolation causes severe psychological effects in humans, but their neural
bases remain poorly understood. 2 weeks (but not 24 hr) of social isolation stress (SIS) …
bases remain poorly understood. 2 weeks (but not 24 hr) of social isolation stress (SIS) …
Action and reaction: the biological response to siRNA and its delivery vehicles
RNA interference (RNAi)-based therapeutics have significant potential for the treatment of
human disease. Safe and effective delivery of RNA to target tissues remains a major barrier …
human disease. Safe and effective delivery of RNA to target tissues remains a major barrier …
siRNA-Finder (si-Fi) software for RNAi-target design and off-target prediction
S Lück, T Kreszies, M Strickert, P Schweizer… - Frontiers in Plant …, 2019 - frontiersin.org
RNA interference (RNAi) is a technique used for transgene-mediated gene silencing based
on the mechanism of posttranscriptional gene silencing (PTGS). PTGS is an ubiquitous …
on the mechanism of posttranscriptional gene silencing (PTGS). PTGS is an ubiquitous …
Advances in siRNA delivery approaches in cancer therapy: challenges and opportunities
Advancements in the clinical applications of small interfering RNA (siRNA) in cancer therapy
have opened up new possibilities for precision medicine. siRNAs, as powerful genetic tools …
have opened up new possibilities for precision medicine. siRNAs, as powerful genetic tools …
Human TNRC6A is an Argonaute-navigator protein for microRNA-mediated gene silencing in the nucleus
K Nishi, A Nishi, T Nagasawa, K Ui-Tei - Rna, 2013 - rnajournal.cshlp.org
GW182 family proteins play important roles in microRNA (miRNA)-mediated gene silencing.
They interact with Argonaute (Ago) proteins and localize in processing bodies, which are …
They interact with Argonaute (Ago) proteins and localize in processing bodies, which are …
[HTML][HTML] A computational approach to design potential siRNA molecules as a prospective tool for silencing nucleocapsid phosphoprotein and surface glycoprotein …
An outbreak, caused by an RNA virus, SARS-CoV-2 named COVID-19 has become
pandemic with a magnitude which is daunting to all public health institutions in the absence …
pandemic with a magnitude which is daunting to all public health institutions in the absence …
New insights on the integrated management of plant diseases by RNA strategies: Mycoviruses and RNA interference
IT Bocos-Asenjo, J Niño-Sánchez, M Ginésy… - International journal of …, 2022 - mdpi.com
RNA-based strategies for plant disease management offer an attractive alternative to
agrochemicals that negatively impact human and ecosystem health and lead to pathogen …
agrochemicals that negatively impact human and ecosystem health and lead to pathogen …