In the mammalian genome, DNA methylation is an epigenetic mechanism involving the
transfer of a methyl group onto the C5 position of the cytosine to form 5-methylcytosine. DNA …

Protein quality control is vital for all living cells and sophisticated molecular mechanisms
have evolved to prevent the excessive accumulation of unfolded proteins. High-temperature …

Astroglia from the postnatal cerebral cortex can be reprogrammed in vitro to generate
neurons following forced expression of neurogenic transcription factors, thus opening new …

Background Human pluripotent stem cells (hPSCs) provide powerful models for studying
cellular differentiations and unlimited sources of cells for regenerative medicine. However, a …

To form protrusions like neurites, cells must coordinate their induction and growth. The first
requires cytoskeletal rearrangements at the plasma membrane (PM), the second requires …

Transcription factor Foxm1 plays a critical role during embryonic development and its
expression is repressed during retinoic acid (RA)-induced differentiation of pluripotent P19 …

Human pluripotent stem cells, such as embryonic stem cells (hESCs) and induced
pluripotent stem cells (iPSCs), have the unique abilities of differentiation into any cell type of …

Several hundred genes have been identified to contribute to epilepsy—the disease affecting
65 million people worldwide. One of these genes is GNAO1 encoding Gαo, the major …

Purpose: The potential of metastasis can be predicted from clinical features like tumor size,
histologic grade, and gene expression patterns. We examined the whole-genome …

Global gene expression analysis of human embryonic stem cells (hESCs) that differentiate
into neural cells would help to further define the molecular mechanisms involved in …