Development of bile acid activated receptors hybrid molecules for the treatment of inflammatory and metabolic disorders
The farnesoid-x-receptor (FXR) and the G protein bile acid activated receptor (GPBAR) 1 are
two bile acid activated receptors highly expressed in entero-hepatic, immune, adipose and …
two bile acid activated receptors highly expressed in entero-hepatic, immune, adipose and …
Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in …
Conclusions: By genetic and pharmacological approaches, we demonstrated that GPBAR1
and CYSLTR1 mutually interact in the development of DILI. A combinatorial approach …
and CYSLTR1 mutually interact in the development of DILI. A combinatorial approach …
Discovery of a Potent and Orally Active Dual GPBAR1/CysLT1R Modulator for the Treatment of Metabolic Fatty Liver Disease
S Fiorucci, P Rapacciuolo, B Fiorillo… - Frontiers in …, 2022 - frontiersin.org
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are two
highly prevalent human diseases caused by excessive fat deposition in the liver. Although …
highly prevalent human diseases caused by excessive fat deposition in the liver. Although …
[PDF][PDF] 小儿麻甘颗粒联合孟鲁司特钠对支气管肺炎患儿炎症指标的影响
饶继林 - 中国医学创新, 2018 - zgyxcx.com
目的: 观察小儿麻甘颗粒联合孟鲁司特钠对支气管肺炎患儿炎症指标的影响. 方法: 随机将2022
年1—10 月赣州市南康区第一人民医院收治78 例支气管肺炎患儿分为两组, 各39 例 …
年1—10 月赣州市南康区第一人民医院收治78 例支气管肺炎患儿分为两组, 各39 例 …
[PDF][PDF] DOTTORATO IN SCIENZA DEL FARMACO XXXIII CICLO 2018/2020
PER LA SALUTE - fedoa.unina.it
Metabolic and inflammatory diseases, affecting the liver and gastrointestinal system, are
very widespread and often their pathogenesis is still unknown. Because these disorders …
very widespread and often their pathogenesis is still unknown. Because these disorders …