Lung cancers: molecular characterization, clonal heterogeneity and evolution, and cancer stem cells

U Testa, G Castelli, E Pelosi - Cancers, 2018 - mdpi.com
Lung cancer causes the largest number of cancer-related deaths in the world. Most (85%) of
lung cancers are classified as non-small-cell lung cancer (NSCLC) and small-cell lung …

The role of miRNAs in regulating gene expression networks

AM Gurtan, PA Sharp - Journal of molecular biology, 2013 - Elsevier
MicroRNAs (miRNAs) are key regulators of gene expression. They are conserved across
species, expressed across cell types, and active against a large proportion of the …

Anatomically and functionally distinct lung mesenchymal populations marked by Lgr5 and Lgr6

JH Lee, T Tammela, M Hofree, J Choi, ND Marjanovic… - Cell, 2017 - cell.com
The diversity of mesenchymal cell types in the lung that influence epithelial homeostasis and
regeneration is poorly defined. We used genetic lineage tracing, single-cell RNA …

Stem cells marked by the R-spondin receptor LGR5

BK Koo, H Clevers - Gastroenterology, 2014 - Elsevier
Since the discovery of LGR5 as a marker of intestinal stem cells, the field has developed
explosively and led to many new avenues of research. The inner workings of the intestinal …

[HTML][HTML] Biology of MiR-17-92 cluster and its progress in lung cancer

X Zhang, Y Li, P Qi, Z Ma - International journal of medical sciences, 2018 - ncbi.nlm.nih.gov
MicroRNAs, a class of short endogenous RNAs, acting as post-transcriptional regulators of
gene expression, mostly silence gene expression via binding imperfectly matched …

Systemically circulating viral and tumor-derived microRNAs in KSHV-associated malignancies

PE Chugh, SH Sin, S Ozgur, DH Henry… - PLoS …, 2013 - journals.plos.org
MicroRNAs (miRNAs) are stable, small non-coding RNAs that modulate many downstream
target genes. Recently, circulating miRNAs have been detected in various body fluids and …

[HTML][HTML] WNT signaling in lung repair and regeneration

AA Raslan, JK Yoon - Molecules and cells, 2020 - Elsevier
The lung has a vital function in gas exchange between the blood and the external
atmosphere. It also has a critical role in the immune defense against external pathogens and …

mir‐17‐92: a polycistronic oncomir with pleiotropic functions

V Olive, Q Li, L He - Immunological reviews, 2013 - Wiley Online Library
Neoplastic transformation is caused by accumulation of genetic lesions that ultimately
convert normal cells into tumor cells with uncontrolled proliferation and survival, unlimited …

A tumor suppressor role for C/EBPα in solid tumors: more than fat and blood

AR Lourenço, PJ Coffer - Oncogene, 2017 - nature.com
The transcription factor CCAAT/enhancer-binding protein alpha (C/EBPα) plays a critical
role during embryogenesis and is thereafter required for homeostatic glucose metabolism …

Knockdown of circRNA-Memo1 reduces hypoxia/reoxygenation injury in human brain endothelial cells through miRNA-17-5p/SOS1 axis

X Ren, YX Jing, ZW Zhou, JW Yang - Molecular Neurobiology, 2022 - Springer
Circ-Memo1 has been proved to be upregulated in ischemia–reperfusion induced acute
injury of kidney tissues. However, the potential role of circ-Memo1 in cerebral …