Redefining serological diagnostics with immunoaffinity proteomics

J Walter, Z Eludin, AP Drabovich - Clinical Proteomics, 2023 - Springer
Serological diagnostics is generally defined as the detection of specific human
immunoglobulins developed against viral, bacterial, or parasitic diseases. Serological tests …

[HTML][HTML] Predictors of Successful Testicular Sperm Extraction: A New Era for Men with Non-Obstructive Azoospermia

A Kaltsas, S Stavros, Z Kratiras, A Zikopoulos… - Biomedicines, 2024 - mdpi.com
Background/Objectives: Non-obstructive azoospermia (NOA) is a severe form of male
infertility characterized by the absence of sperm in the ejaculate due to impaired …

Mass spectrometry-based untargeted approaches to reveal diagnostic signatures of male infertility in seminal plasma: A new laboratory perspective for the clinical …

M Preianò, S Correnti, TA Butt, G Viglietto… - International Journal of …, 2023 - mdpi.com
Male infertility has been recognized as a global health problem. Semen analysis, although
considered the golden standard, may not provide a confident male infertility diagnosis alone …

A role of the TEX101 interactome in the common aetiology behind male subfertility and testicular germ cell tumor

J Burton, MW Wojewodzic, TB Rounge… - Frontiers in …, 2022 - frontiersin.org
Patients who develop testicular germ cell tumours (TGCT) are at higher risk to be subfertile
than the general population. The conditions are believed to originate during foetal life …

Germ Cell–Specific Proteins AKAP4 and ASPX Facilitate Identification of Rare Spermatozoa in Non-Obstructive Azoospermia

J Zhang, M Kanoatov, K Jarvi, A Gauthier-Fisher… - Molecular & Cellular …, 2023 - ASBMB
Non-obstructive azoospermia (NOA), the most severe form of male infertility, could be
treated with intracytoplasmic sperm injection, providing spermatozoa were retrieved with the …

Seminal plasma testis expressed sequence (TEX)-101 as a biomarker for the qualitative assessment of male factor infertility: A case-control study

N Kumar, KN Deepthi, S Padugupati, S Ghose… - European Journal of …, 2023 - Elsevier
Objective The study was conducted to assess the role of seminal plasma Testis Expressed
Sequence (TEX)-101 as a biomarker of male infertility. Study design The study was …

Identification and quantification of human relaxin proteins by immunoaffinity-mass spectrometry

Y Rais, AP Drabovich - Journal of Proteome Research, 2024 - ACS Publications
The human relaxins belong to the Insulin/IGF/Relaxin superfamily of peptide hormones, and
their physiological function is primarily associated with reproduction. In this study, we …

The proteomic toolbox for identification, quantification, and characterization of polyclonal antibodies

W Tang, AP Drabovich - BioRxiv, 2023 - biorxiv.org
Recent advances in proteomics and mass spectrometry facilitated the in-depth
characterization of monoclonal antibodies and enabled innovative approaches for the …

The Application of Ejaculate-Based Shotgun Proteomics for Male Infertility Screening

T Shkrigunov, V Zgoda, P Klimenko, A Kozlova… - Biomedicines, 2023 - mdpi.com
Problems with the male reproductive system are of both medical and social significance. As
a rule, spermatozoa and seminal plasma proteomes are investigated separately to assess …

Germ cell-specific proteins ACRV1 and AKAP4 facilitate identification of rare spermatozoa in semen of non-obstructive azoospermia patients

J Zhang, M Kanoatov, K Jarvi, A Gauthier-Fisher… - MedRxiv, 2022 - medrxiv.org
ABSTRACT Non-obstructive azoospermia (NOA), the most severe form of male infertility due
to testicular failure, could be treated with intra-cytoplasmic sperm injection (ICSI), providing …